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The effectivity and feasibility of integrating nondispensing pharmacists into primary healthcare centres


- candidate number16000
- NTR NumberNTR4389
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR7-jan-2014
- Secondary IDs13-432/C and 80-83600-98-10206 METC-protocolnumber and ZonMw dossier number
- Public TitleThe effectivity and feasibility of integrating nondispensing pharmacists into primary healthcare centres
- Scientific TitleOptimizing pharmacotherapy by redefining the role of the pharmacist: integration of the nondispensing pharmacist in the primary care team.
- ACRONYMPOINT (Pharmacotherapy Optimization through Integration of Nondispending pharmacist in a primary care Team)
- hypothesisThe integration of a pharmacist in the primary care, which has up to now not been studied in the Netherlands, could enable more efficient interventions to resolve drug therapy problems and help to build collaborative working relationships between pharmacists and physicians.
- Healt Condition(s) or Problem(s) studiedPolypharmacy, Pharmacist, Drug Utilization Review , Medication Therapy Management , Primary care, Hospitalization, Older adults, Medication errors
- Inclusion criteria- Patients ≥ 60 years; - Polypharmacie (≥ 5 different chronic medications); - Use of cardiovasculair medication (ATC B/C); - Multi-morbidity (Frailty index ≥ 0.20)
- Exclusion criteriaNone
- mec approval receivedyes
- multicenter trialno
- randomisedno
- groupParallel
- Type2 or more arms, non-randomized
- Studytypeintervention
- planned startdate 3-mrt-2014
- planned closingdate31-okt-2016
- Target number of participants8550
- InterventionsIn a prospective, non-randomised controlled intervention with pre/post comparison (quasi experimental design) the outcomes of three implementation strategies with three models of pharmaceutical care provision will be compared: A) In the nondispensing pharmacist arm, 10 GP practices with a total of 250000 patients will be involved with an integrated pharmacist as a member of the primary healthcare team; B) In the community pharmacists with additional training arm, 10 pharmacists and their collaborating GP practices will be involved. The pharmacists will attend the ‘PIAF’ or the ‘Service ApotheekFarmacotherapie Expert’ clinical pharmacy course and is th trefore expected to work according to the guideline polypharmacy in the elderly. C) In the usual care arm, 10 pharmacists will be involved with their collaborating GP practices.
- Primary outcomemedication-related hospital admissions in elderly patients with multimorbidity, cardiovascular disease and polypharmacy.
- Secondary outcomecardiovascular events, quality indicators including blood pressure, laboratory markers and prescription indicators, the consumption of health care and related costs, prescription changes in elderly patients with multimorbidity, cardiovascular disease and polypharmacy.
- TimepointsRoutine healthcare data from primary care can be anonymously linked to the Achmea/Agis Health database. The extraction of patient data will be performed by the U-PRIM system, a software application that is installed in all participating general practices. Information will be available of the electronic medical records (EMRs) in each general practice, combined with SFK data from the community pharmacies including medication dispensing data and combined with the Achmea/Agis Health database including reimbursement data.Outcomes will be extracted from the database during the intervention period of 12 months and 12 months prior to the intervention. Outcomes will be extracted from the database from the ‘care as usual’ arm and from the ‘pharmacist with additional training’ arm in the same period as the intervention of the nondispensing pharmacist will take place. As all required data are already routinely collected, all datacollection is prospective, also in the pre-intervention period. No changes in this data collection routine are foreseen during the study period. Whether hospital admissions are related to medication will be assessed by two independent clinical pharmacists based on discharge information, medical history and medication history, according the algorithm by Kramer et al.
- Trial web sitewww.juliuscentrum/apotheker
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIESDr. A.J. Leendertse
- CONTACT for SCIENTIFIC QUERIESDr. A.J. Leendertse
- Sponsor/Initiator ZonMw: The Netherlands Organization for Health Research and Development, Achmea
- Funding
(Source(s) of Monetary or Material Support)
ZON-MW, The Netherlands Organization for Health Research and Development
- Publications
- Brief summaryThe prevalence of suboptimal prescribing of medications is considerable. Patients are often undertreated or subjected to interacting drug treatments that are potentially harmful. This frequently results in medication related hospital admissions that are potentially preventable. Improvements to the healthcare system are needed in order to maximize the benefits of pharmacotherapy. It has been demonstrated that pharmacists can improve prescribing, reduce healthcare utilization and medication costs, thus contributing to clinical improvements in many chronic medical conditions. The integration of a pharmacist in the primary care team, as the key provider of pharmaceutical care to individual patients, has the potential to address many of the present barriers to effective pharmaceutical care, by improving access to patient information, addressing logistical communication challenges between pharmacists and GPs (general practitioners). The integration of a pharmacist in the primary care, which has up to now not been studied in the Netherlands, could enable more efficient interventions to resolve drug therapy problems and help to build collaborative working relationships between pharmacists and physicians. This project is designed to study the effect and the feasibility of integrating a nondispensing pharmacists into primary healthcare centres. In this project we intend to compare adverse medication related events and clinical parameters of the pharmaceutical care process in elderly patients with multimorbidity and polypharmacy, in three different models of pharmaceutical care delivery in the primary care setting: A) a nondispensing pharmacist as an integral member of the primary healthcare team based in the GP practice (nondispensing pharmacist group) B) a pharmacist in a community pharmacy with a predefined training, performing structured medication reviews (education group) C) a pharmacist in a community pharmacy (control group of usual care). Medication related hospital admissions will be the primary outcome measured. The secondary outcomes are changes in prescription (number of drugs, number of prescriptions, discontinuation of drugs, starting a new drug, switch to a new type of drugs, dose, strength, refill compliance), prescription indicators, monitoring of effective and safe pharmacotherapy, bloodpressure, laboratory markers, number of medication reviews, cardiovascular events, number of referrals to specialists, and number of documented falls. As hospitalisations are often a cost driver, keeping patients out of the hospital is an important goals of the care provided by the pharmacists and might be cost-effective. By improving pharmaceutical care within primary care the quality of the care might improve and may lead to cost savings in secondary care. We will perform a cost analysis mainly based on resource utilisation to provide more information on costs within different groups of this the study. The outcomes of interest in this economic evaluation will be: hospitalisation costs, annual resource utilisation costs, annual medication costs and costs of the nondispensing pharmacist.
- Main changes (audit trail)
- RECORD7-jan-2014 - 31-mrt-2014


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