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Casein in milk as a functional ingredient for the prevention of sarcopenia


- candidate number16377
- NTR NumberNTR4429
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR6-feb-2014
- Secondary IDs13-3-063.3 METC
- Public TitleCasein in milk as a functional ingredient for the prevention of sarcopenia
- Scientific TitleCasein in milk as a functional ingredient for the prevention of sarcopenia
- ACRONYMCasein in Milk
- hypothesisCasein ingested within a normal milk matrix results in a more rapid digestion and amino acid absorption, resulting in greater amino acid availability and post-prandial muscle protein accretion as compared to the ingestion of isolated casein (without a milk matrix)
- Healt Condition(s) or Problem(s) studiedSarcopenia
- Inclusion criteria- Males - Aged between 65-85 years - Healthy, recreationally active - BMI < 30 kg/m2
- Exclusion criteria- Female - Smoking - Allergies to milk proteins (whey or casein) - Arthritic conditions - Over the counter antacids - Diabetes mellitus type 1 and type 2 - A history of neuromuscular problems - Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications). - Participation in any regular exercise program - Chronic use of gastric acid suppressing medication or anti-coagulants - Unstable weight over the last three months - Pathologies of the gastrointestinal tract
- mec approval receivedno
- multicenter trialno
- randomisedyes
- masking/blindingDouble
- controlNot applicable
- groupParallel
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 1-apr-2014
- planned closingdate1-apr-2015
- Target number of participants32
- InterventionsSubjects will be randomly assigned to consume either a drink containing isolated casein or casein in the normal milk matrix. By the use of stable isotope methodology we will assess the digestion and absorption kinetics of the ingested protein source and the fractional synthetic rate (FSR) of muscle proteins in the fasting and fed state in an in vivo human setting.
- Primary outcomefractional synthetic rate
- Secondary outcome Exogenous phenylalanine rate of appearance and plasma availability of phenylalanine. Total rate of phenylalanine appearance and disappearance Endogenous phenylalanine rate of appearance
- Timepointsbaseline 2 h 5 h
- Trial web site-
- statusplanned
- CONTACT FOR PUBLIC QUERIESDr. L.J.C. Loon, van
- CONTACT for SCIENTIFIC QUERIESDr. L.J.C. Loon, van
- Sponsor/Initiator Maastricht University Medical Center (MUMC+)
- Funding
(Source(s) of Monetary or Material Support)
Dairy Research Institute
- Publications
- Brief summary
- Main changes (audit trail)
- RECORD6-feb-2014 - 7-apr-2014


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