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Weight loss with protein and resistance exercise in overweight older adults


- candidate number17637
- NTR NumberNTR4556
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR1-mei-2014
- Secondary IDsMETc: IRBN2014001 Amsterdam University of Applied Sciences
- Public TitleWeight loss with protein and resistance exercise in overweight older adults
- Scientific TitleEffect of a hypocaloric high-protein diet and resistance exercise on body composition, muscle strength, physical functioning and quality of life during a weight loss trial in overweight older adults
- ACRONYMWelPrex
- hypothesisA high protein diet and resistance exercise have a positive effect on fat free mass, fat mass, muscle strength, physical functioning and quality of life compared to regular dietary and exercise advice according to CBO guidelines for treatment of obesity in an overweight population of older adults.
- Healt Condition(s) or Problem(s) studiedOverweight, Adipositas
- Inclusion criteria1. BMI>28 and/or BMI > 25 with a waist circumference > 88 cm (women) or > 102 cm (men)
2. age>=55
3. Willingness and ability to comply with the protocol, including:
A. following a hypocaloric diet
B. participation in study visits
C. ability to comply with the complete study protocol
D. ability to understand and fill out questionnaires
E. physiotherapist’s professional view that the subject is physically fit and it is safe to participate in the resistance exercise program.
- Exclusion criteria1. renal failure
2. cardiovascular disease
3. Diabetes Mellitus with insulin
4. exercise asthma
5. dysfunction of joints
6. use of antidepressant (< 1 year)
7. thyroid dysfunction (use of thyroid medication with changed dosage in last 12 months. When stable, subjects can be included.)
8. Participation in a resistance exercise and/or weight loss program three months before starting and during the study
9. Current alcohol or drug abuse in opinion of the sponsor-investigator
10. Known allergy to milk and milk products
11. Known galactosaemia
12. Sponsor-investigator's uncertainty about the willingness or ability of the subject to comply with the protocol requirements
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingNone
- controlActive
- groupParallel
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 1-mei-2014
- planned closingdate31-dec-2014
- Target number of participants120
- InterventionsDuration of intervention: 10 weeks.
Subjects are randomized into:
1. control group (regular diet and exercise advice according to CBO guideline) or,
2. high protein diet group (high protein diet and exercise advice according to CBO guideline) or,
3. exercise group (regular diet and exercise program according to CBO guideline) or,
4. high protein diet and exercise group (both high protein diet and exercise program).

The regular dietary advice consists of 0.8 g/kg and the high protein dietary advice of 1.3 g/kg body weight (using current weight for BMI < 30 kg/m2 or using weight at BMI 27,5 kg/m2 for BMI ≥ 30 kg/m2).

Exercise training in groups 3 and 4 involve resistance exercise (circuit training) combined with an aerobic warming up and cooling down 3 days a week during 60 minutes.
- Primary outcomeFat free mass
- Secondary outcomeMuscle strength, physical functioning, quality of life
- Timepoints1. baseline
2. after 5 weeks
3. after 10 weeks
- Trial web site
- statusstopped: trial finished
- CONTACT FOR PUBLIC QUERIES A.M. Verreijen
- CONTACT for SCIENTIFIC QUERIESDr. Ir. Peter J.M. Weijs
- Sponsor/Initiator Hogeschool Amsterdam/Amsterdam University of Applied Sciences
- Funding
(Source(s) of Monetary or Material Support)
Hogeschool van Amsterdam/Amsterdam University of Applied Sciences
- PublicationsN/A
- Brief summaryTo investigate the effect of a high protein diet and resistance exercise on body composition, muscle strength, physical functioning and quality of life in overweight older adults during a 10 week weight loss period.
- Main changes (audit trail)
- RECORD1-mei-2014 - 3-jan-2017


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