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Denkprocessen meten met electroden in de hersenen


- candidate number17973
- NTR NumberNTR4616
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR27-mei-2014
- Secondary IDsiEEGstudy 
- Public TitleDenkprocessen meten met electroden in de hersenen
- Scientific TitleIntracranial registration in patients with refractory epilepsy - an integrative analysis of brain signals in response tot sensory stimuli
- ACRONYMiEEGstudy
- hypothesisTo enhance insight on the coding of sensory stimuli by signal analyses
- Healt Condition(s) or Problem(s) studiedEpilepsy
- Inclusion criteria Medically refractory epilepsy
Diagnostic workup up till that moment has not led to decline the patient for resective epilepsy surgery
A suspected (neo-)cortical seizure focus at the surface of the brain
Planned implantation of intracranial electrodes
Incapacitating epilepsy or seizures
Minimum age 18 years
Inclusion criteria for healthy control:
Voluntary controls will be selected based on the gender and age distribution of the patients programmed for grid implantation surgery.
- Exclusion criteria Patients with (co-existent) psychogenic, non-epileptic attacks, or low IQ (below 70).
(post-ictal) psychosis during the registration period will lead to exclusion from the study.
- mec approval receivedno
- multicenter trialno
- randomisedno
- group[default]
- TypeSingle arm
- Studytypeobservational
- planned startdate 1-sep-2014
- planned closingdate
- Target number of participants0
- InterventionsNo interventions are planned
- Primary outcomeTo study the patterns and topographical distribution of the electrical signal generated in cortical neurons during the processing of sensory stimuli (of which the nature will depend on the primary function of the cortical area under investigation) in epileptic patients under intracranial registration.
- Secondary outcome The secondary objectives are:
1. To study the phase-amplitude relationship between different frequency bands in the neural signal.
2. To characterize the brain activation patterns during sensory stimulation by fMRI in epileptic patients before the implantation of the electrodes and compare it with the fMRI activation patterns obtained from healthy volunteers.
3. To identify the patterns in the ECoG signal that are correlated with the patterns of activation obtained with fMRI in order to understand better how the neural processes are reflected in neuroimaging studies.
4. To collect quantitative information that can be used for future research projects.
- Timepoints7T fMRI scan (presurgical) and postoperative test. No other timepoints.
- Trial web site
- statusplanned
- CONTACT FOR PUBLIC QUERIESDr. R. Rouhl
- CONTACT for SCIENTIFIC QUERIESDr. R. Rouhl
- Sponsor/Initiator Maastricht University Medical Center (MUMC+)
- Funding
(Source(s) of Monetary or Material Support)
None
- Publications
- Brief summary
- Main changes (audit trail)
- RECORD27-mei-2014 - 28-jun-2014


  • Indien u gegevens wilt toevoegen of veranderen, kunt u een mail sturen naar nederlands@trialregister.nl