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A systems biology approach to ocular inflammation


- candidate number18033
- NTR NumberNTR4630
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR4-jun-2014
- Secondary IDsMETC: 14/065 ABR: NL46874.041.13
- Public TitleA systems biology approach to ocular inflammation
- Scientific TitleA systems biology approach to ocular inflammation
- ACRONYM
- hypothesisA systems biology approach is an hypothesis free study that looks at multiple layers within one patient (genome, epigenome, proteome, metabolome)
- Healt Condition(s) or Problem(s) studiedUveitis, Macular degeneration, Ocular inflammation
- Inclusion criteria- 18-95 years of age
- diagnosed with non-infectious uveitis (anterior, intermediate, posterior, panuveitis, scleritis) OR
- inflammatory corneal disease (keratokonus, Fuchs endothelial corneal dystrophy) OR
- idiopathic inflammatory orbital disease OR
- age-related macular degeneration
- Exclusion criteria- (acquired) immune deficiencies
- inadequate knowledge of Dutch
- current use of systemic immunomodulatory agents, biologicals or cyclosporine
- IV corticosteroids in last 14 days before inclusion
- mec approval receivedyes
- multicenter trialno
- randomisedno
- group[default]
- TypeSingle arm
- Studytypeobservational
- planned startdate 1-dec-2013
- planned closingdate1-dec-2017
- Target number of participants440
- Interventionsnone (observational)
- Primary outcomeWe aim to employ an "omics"-driven systems biology approach on patients with ocular inflammation in order to identify the molecular pathways underlying the pathogenesis of ocular and orbital inflammation and develop clinically usefull markers to predict disease outcome and treatment responses (eg biomarkers). For this we study multiple layers of the immune system (genome, epigenome, proteome, metabolome and cellsubsets).
- Secondary outcomeTo identify new therapeutical targets for potential use in future clinical studies by evaluation of novel biomarkers in functional models
- TimepointsVenous blood is drawn at active inflammation
- Trial web site
- statusplanned
- CONTACT FOR PUBLIC QUERIES Jonas Kuiper
- CONTACT for SCIENTIFIC QUERIES Jonas Kuiper
- Sponsor/Initiator University Medical Center Utrecht (UMCU)
- Funding
(Source(s) of Monetary or Material Support)
University Medical Center Utrecht (UMCU)
- Publications
- Brief summary
- Main changes (audit trail)
- RECORD4-jun-2014 - 1-jul-2014


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