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Online training to reduce anxiety and depressive symptoms


- candidate number17728
- NTR NumberNTR4660
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR21-mei-2014
- Secondary IDs2013-OP-3023 METC Psychology department UvA
- Public TitleOnline training to reduce anxiety and depressive symptoms
- Scientific TitleCognitive bias modification and working memory training for anxiety and depression: A randomized controlled trial
- ACRONYM
- hypothesisThe aim of the current study is to test whether online training of a positive attentional bias and/or working memory capacity can reduce anxiety and/or depressive symptoms in adults with heightened emotional symptoms.
- Healt Condition(s) or Problem(s) studiedAnxiety, Depression, Working Memory, Attention, Online Learning
- Inclusion criteria> 18 years old
Interest in reducing anxious or depressive symptoms. Participants can choose the depression or anxiety part based on their major complaints. The training programme is identical for both, but assessments differ somewhat.
- Exclusion criteriaNone.
However, participants are screened using the State-Trait Anxiety Inventory (STAI, trait version) for anxiety or the Beck Depression Inventory (BDI) for depression.
For scores below 14 (BDI) or 40 (ZBV) they receive feedback that it's not necesarry to participate in training, but that they are free to continue. For scores above 29 (BDI) or 46 (ZBV) they are adviced to contact there doctor to seek professional help, but are still free to participate.
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingSingle
- controlPlacebo
- groupFactorial
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 1-jun-2013
- planned closingdate1-jun-2015
- Target number of participants400
- InterventionsParticipants complete 11 30-minute sessions of online computer training (during +/- 4 weeks). Each session consists of 2 types of training:
1. Attention bias training: visual search task (VST);
2. Working memory training: emotional block-tapping task (ECT)

Participants are randomized over 4 groups, with a factorial design:
1 VST real + ECT real
2 VST real + ECT placebo
3 VST placebo + ECT real
4 VST placebo + ECT placebo
- Primary outcomeFor anxiety part:
- State-Trait Anxiety Inventory (STAI, trait version)

For depression part:
- Beck Depression Inventory (BDI)
- Secondary outcomeModerators:
-severity of complaints pre-training
-number of sessions completed

For both anxiety and depression:
- Rosenberg self-esteem scale (RSES)
- Alcohol Use Disorders Identification Test (AUDIT-C, short version: 3 items)
- Mood (depression or anxiety) and motivation before each training session
- Mood (depression or anxiety) since previous session (Time Line Follow Back)
- Client satisfaction questionnaire and training-specific evaluation questions (only at post-training)

Change in cognitive processes (not at FU 1 and 2):
- WM capacity: Self Ordered Pointing Task (SOPT)
- Attentional bias: Emotional Visual Search Task (EVST)

For anxiety part only :
- Liebowitz Social Anxiety Scale (LSAS)
- Beck’s Depression Inventory (BDI)
- Penn State Worry Questionnaire abbreviated (PSWQ-a; 8 items)
+ If any of these symptoms indicated in the screening questionnaire based on SCID interview:
- Panic Disorder Severity Scale Self-Report (PDSS-SR)
- Fear Questionnaire (FQ)
- Obsessive Compulsive Inventory-Revised (OCI-R)
- PTSD Symtom Scale (PSS-SR)

For depression part only:
- Ruminative Response Scale (RRS)
- State-Trait Anxiety Inventory (STAI trait version)
- Attentional Control Scale (ACS)
- TimepointsPre-training
Half-way training (after 6 sessions)
Post-training
Follow-up 1: 1 month
Follow-up 2: 2 months
Follow-up 3: 3 months
- Trial web sitewww.impliciet.eu
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIESDr. E. Salemink
- CONTACT for SCIENTIFIC QUERIESDr. E. Salemink
- Sponsor/Initiator University of Amsterdam (UvA)
- Funding
(Source(s) of Monetary or Material Support)
NWO
- PublicationsN/A
- Brief summaryIn this study, we test an online training program designed to reduce anxiety and depression symptoms in symptomatic adults. Participants are recruited online and randomly assigned to one of 4 training conditions (2 (experimental) x 2 (placebo) factorial design). Training focuses on attentional bias and cognitive control (working memory).
Anxiety and depressive symptoms and secondary outcome measures are assessed at pre-, half-way- and post-training and 1, 2 and 3 months follow-up.
- Main changes (audit trail)
- RECORD21-mei-2014 - 20-aug-2014


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