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van CCT (UK)


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van CCT (UK)


A comparison between two diagnostic tools to identify dynamic hyperinflation in COPD-patients:
1. Metronome-Paced hyperventilation and
2. Cardio pulmonary exercise test



- candidate number19372
- NTR NumberNTR4764
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR29-aug-2014
- Secondary IDsRTPO 924 Regionale Toetsingscommissie PatiŽntgebonden Onderzoek Leeuwarden
- Public TitleA comparison between two diagnostic tools to identify dynamic hyperinflation in COPD-patients:
1. Metronome-Paced hyperventilation and
2. Cardio pulmonary exercise test
- Scientific TitleA comparison between two diagnostic tools to identify dynamic hyperinflation in COPD-patients:
1. Metronome-Paced hyperventilation with inspiratory capacity manoeuvres.
2. CPET with inspiratory capacity manoeuvres.
- ACRONYM
- hypothesisDynamic hyperinflation in patients with COPD is not different in cardio pulmonary exercise testing (CPET) from dynamic hyperinflation in metronome paced hyperventilation test (MPH).
- Healt Condition(s) or Problem(s) studiedCOPD, Dynamic hyperinflation
- Inclusion criteria1. COPD with FEV1/VC< LLN. (All GOLD classes included)
2. Age > 17 years.
3. Sent for CPET (all indications) by pulmonologist.
- Exclusion criteria1. Not able to perform Inspiratory Capacity manoeuvre well
2. No informed consent
- mec approval receivedyes
- multicenter trialno
- randomisedno
- group[default]
- TypeSingle arm
- Studytypeobservational
- planned startdate 1-sep-2014
- planned closingdate1-sep-2015
- Target number of participants110
- InterventionsAddition of Metronome paced hyperventilation test prior to CPET: in both tests IC manoeuvres shall be performed as a measure for dynamic hyperinflation.
All participants will perform both tests.
CPET (bycicle): IC manouevres: basal and at maximum exercise.
MPH: IC manoeuvres: basal and after 20 sec ventilating at double resting respiratory rate.
- Primary outcomeDifference in IC manoeuvre (in ml) between basal and post-test value of both tests (CPET and MPH).
- Secondary outcomenone
- TimepointsSee above: interventions
- Trial web site
- statusplanned
- CONTACT FOR PUBLIC QUERIES J. Maten, van der
- CONTACT for SCIENTIFIC QUERIES J. Maten, van der
- Sponsor/Initiator Medical Center Leeuwarden
- Funding
(Source(s) of Monetary or Material Support)
None
- Publications
- Brief summaryReferring to paper of AJMC Laheije et al (Clin Physiol Funct Imaging 2013;33:62-69) in this observational study, we want to investigate whether in our hands (Medical Centre Leeuwarden, pulmonary function department) there is no difference between dynamic hyperinflation (assessed by change in inspiratory capacity) in patients with COPD between metronome paced hyperventilation test (MPH) and cardio pulmonary exercise testing (CPET) as gold standard test.
- Main changes (audit trail)
- RECORD29-aug-2014 - 27-sep-2014


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