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Neural plasticity, hearing loss and tinnitus: changes in tonotopic maps of the auditory cortex


- candidate number19540
- NTR NumberNTR4811
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR24-sep-2014
- Secondary IDsNL44470.042.13 
- Public TitleNeural plasticity, hearing loss and tinnitus: changes in tonotopic maps of the auditory cortex
- Scientific TitleNeural plasticity, hearing loss and tinnitus: changes in tonotopic maps of the auditory cortex
- ACRONYM
- hypothesis
- Healt Condition(s) or Problem(s) studiedHearing loss, Tinnitus, fMRI
- Inclusion criteria- No hearing loss or reported tinnitus (controls, n=40)
- Hearing loss (Hearing loss group, n=40)
- Tinnitus (Hearing loss and tinnitus group, n=40)
- < 30 dB difference between both ears for all the standard audiometric frequencies
- Adults (18 - 75 yrs.)
- No contraindications for MRI
- Exclusion criteriaNon-compliance with inclusion criteria
- mec approval receivedyes
- multicenter trialno
- randomisedno
- group[default]
- Type[default]
- Studytypeobservational
- planned startdate 1-jan-2015
- planned closingdate1-jan-2017
- Target number of participants120
- InterventionsfMRI measurements while listing to sound fragments.
- Primary outcomeMeasures of tonotopic map reorganisation.
- Secondary outcomeRelation of hearing loss and degree of reorganisation. Two types of hearing loss are going to be studied: steep-sloping hearing loss and gradual sloping hearing loss.
- TimepointsNo longitudinal design; just one time-point
- Trial web site
- statusplanned
- CONTACT FOR PUBLIC QUERIESPhD. C.P. Lanting
- CONTACT for SCIENTIFIC QUERIESPhD. C.P. Lanting
- Sponsor/Initiator University Medical Center Groningen (UMCG)
- Funding
(Source(s) of Monetary or Material Support)
University Medical Center Groningen (UMCG), American Tinnitus Association
- Publications
- Brief summaryWith an increased life expectancy and an ageing population, age-related dysfunctions are becoming more prevalent. The most widespread of all sensory impairments in an ageing population is hearing loss, which is characterized by a loss of sensitivity of the peripheral hearing organ, the inner ear. This peripheral hearing loss is associated with less sensory input available to the brain. Animal research has shown that peripheral hearing loss may cause widespread plastic changes in the brain. Peripheral hearing loss is often associated with tinnitus: about 30% of the people with hearing loss also develop tinnitus. It has been suggested previously that tinnitus and tonotopic reorganisation are causally related. Such cortical reorganisation presumably contributes to the impaired communication skills experienced by humans with hearing loss. With an increasing demand for active participation of the elderly in society, it is crucially important to understand the neurobiological consequences of hearing loss and tinnitus.

The current study employs functional magnetic resonance imaging (fMRI) to investigate the relation between peripheral hearing loss, tinnitus and cortical reorganization. In particular, it aims to map the topographic representation of sound frequency, referred to as tonotopic maps, and how these change as a consequence of tinnitus and hearing loss. It also aims to investigate whether the type of hearing loss is related to the degree of reorganisation.
- Main changes (audit trail)
- RECORD24-sep-2014 - 18-okt-2014


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