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AmCo working memory training


- candidate number19553
- NTR NumberNTR4820
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR26-sep-2014
- Secondary IDs2013-OP-3060 UvA faculty ethics committee
- Public TitleAmCo working memory training
- Scientific TitleWorking memory training for the treatment of amphetamine and cocaine dependence.
- ACRONYMAmCo
- hypothesisWorking memory training increases cognitive control, thereby reducing the amount of amphetamine or cocaine used.
- Healt Condition(s) or Problem(s) studiedSubstance abuse, Cocaine, Cocain addiction, Cocaine dependence, , Memory
- Inclusion criteria1) 18-65 years old
2) primary amphetamine use or primary cocaine use
3) desire to quit their amphetamine/cocaine use
- Exclusion criterian.a.
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingNone
- controlPlacebo
- groupParallel
- TypeSingle arm
- Studytypeintervention
- planned startdate 1-nov-2014
- planned closingdate1-mrt-2016
- Target number of participants250
- Interventions25 day online working memory training, consisting of one working memory task and several questionnaires. There is an adaptive training version and a non-adaptive placebo version.
- Primary outcome1) substance use
2) craving
- Secondary outcome1) use of other substances
2) craving
3) performance on working memory task
- TimepointsT1: creating account, assignment to amphetamine version or cocaine version, first day of training (questionnaires and training)
T2-T24: working memory training and questionnaires
T25: last working memory training and questionnaires.
T26: one-month follow-up on substance use
T27: three-month follow-up on substance use and information on training (training or placebo)
T28-T53: optional working memory training with real training when desired by participant
- Trial web sitewww.impliciet.eu
- statusplanned
- CONTACT FOR PUBLIC QUERIES M.H.J. Schulte
- CONTACT for SCIENTIFIC QUERIES M.H.J. Schulte
- Sponsor/Initiator University of Amsterdam (UvA)
- Funding
(Source(s) of Monetary or Material Support)
University of Amsterdam
- Publications
- Brief summaryOne way to reduce drug use or to even stop is by increasing cognitive control. This can be done by means of working memory training. This study examines the effect of working memory training on amphetamine and cocaine use in adults who want to reduce their use. Potential participants who read the information brochure and sign the informed consent online. Then they perform 25 days of working memory training independently. Subjects are blinded to whether they received the training or placebo variant. Before and after this period they will also complete a number of questionnaires about how much amphetamine or cocaine is used, the reasons for use and opinion about the training.
- Main changes (audit trail)
- RECORD26-sep-2014 - 28-okt-2014


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