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van CCT (UK)

van CCT (UK)

Trial of tyrosine and its effect on working memory in healthy elderly and young people

- candidate number19659
- NTR NumberNTR4846
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR9-okt-2014
- Secondary IDsNL49893.081.14 14/20
- Public TitleTrial of tyrosine and its effect on working memory in healthy elderly and young people
- Scientific TitleA randomized, cross-over, dose-response trial of tyrosine and its effect on working memory in healthy elderly and young people
- hypothesis
- Healt Condition(s) or Problem(s) studiedWorking Memory
- Inclusion criteria• Aged 18-35 years or aged 60-75 years
• Normal and stable weight (BMI 18.5-25 kg/m2 and weight 50-95 kg)
• Willing to abstain from blood donation during the study
• Willing to comply with study procedures
• Willing to accept use of all encoded data, including publication, and the confidential use and storage of all data for at least 15 years.
• Dutch-speaking
• Non-smoking
• Normal or corrected-to-normal vision
- Exclusion criteria• Thyroid problems, such as hyperthyroidism, hypothyroidism, thyroid cancer
• Using medication that can interfere with tyrosine’s action; monoamine oxidase inhibitors and other antidepressants, sympathomimetic amines, and opioids
• Following a low-protein diet as prescribed by a dietician or physician
• Intestinal problems that affect nutrient absorption (such as coeliac disease)
• Parkinson’s Disease
• Depression
• Use of tyrosine supplements
• Being allergic or having a dislike to the product carrier (banana-flavored yoghurt)
• Bad venous access, as judged by the research nurse
• Personnel of Wageningen UR, Division of Human Nutrition, their partner and their first and second degree relatives
• Current participation in other scientific research
• Mini Mental State Examination (MMSE) score < 24 (to exclude cognitive impaired participants, only for elderly participants)
• Estimated IQ <85 (based on Nederlandse Leestest voor Volwassenen (NLV) -score)
• (History of) clinically significant psychiatric disorder
• (History of) clinically significant neurological disorder, such as brain infarct, chronic migraine, major depression
• Under treatment for cardiac or vascular diseases and use of medication for these conditions
• General medical conditions, such as repetitive strain injury (RSI) or sensori-motor handicaps, as judged by the investigator
• Alcohol consumption of more than 14 (women) or 21 (men) units per week
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingDouble
- controlNot applicable
- groupCrossover
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 9-okt-2014
- planned closingdate18-dec-2014
- Target number of participants34
- Interventions100, 150 and 200 mg/kg body weight of tyrosine
- Primary outcomeTyrosine plasma concentrations at T0, T90, T120, T150, T180, T210 and T240 at doses of 100 mg/kg body weight (elderly), 150/kg body weight mg (young and elderly) and 200 mg/kg body weight (elderly)
- Secondary outcomePerformance on the n-back task measured by accuracy (total number of hits) and reaction time (ms) on all doses
- TimepointsT0, T90, T120, T150, T180, T210 and T240
- Trial web site
- statusstopped: trial finished
- CONTACT for SCIENTIFIC QUERIESIr. Ondine Rest, van de
- Sponsor/Initiator Wageningen University (WUR)
- Funding
(Source(s) of Monetary or Material Support)
- Publications
- Brief summary
- Main changes (audit trail)
- RECORD9-okt-2014 - 30-apr-2015

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