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Non-invasive Assessment of Coronary Artery Disease in Patients with Chest Pain.


- candidate number1695
- NTR NumberNTR486
- ISRCTNISRCTN65675235
- Date ISRCTN created26-feb-2007
- date ISRCTN requested18-nov-2005
- Date Registered NTR15-sep-2005
- Secondary IDsN/A 
- Public TitleNon-invasive Assessment of Coronary Artery Disease in Patients with Chest Pain.
- Scientific TitleNon-invasive Assessment of Coronary Artery Disease in Patients with Chest Pain.
- ACRONYMN/A
- hypothesisIn patients presenting with chest pain complaints and an intermediate risk of coronary artery disease, Multi-Slice Computed Tomography (MSCT) will have a higher specificity as compared to myocardial perfusion imaging (MPI). Accordingly, MSCT may serve as an accurate first-line evaluation tool.
- Healt Condition(s) or Problem(s) studiedAngina Pectoris, Coronary artery disease
- Inclusion criteriaAdult patients (having obtained legal majority age) with chest pain complaints and an intermediate pre-test likelihood of CAD (based on the Diamond and Forrester method) with the need for additional imaging studies to evaluate the presence/absence of CAD.
- Exclusion criteriaFertile women, patients with severe renal failure, patients presenting with a known allergy to iodine contrast media, patients included in another clinical trial, patients under guardianship, and patients whose degree of cooperation is incompatible with carrying out the study.
- mec approval receivedyes
- multicenter trialno
- randomisedno
- group[default]
- TypeSingle arm
- Studytypeintervention
- planned startdate 1-okt-2004
- planned closingdate1-okt-2007
- Target number of participants100
- InterventionsMSCT coronary angiography in addition to myocardial perfusion imaging (MPI).
- Primary outcomeMSCT may improve (as compared to MPI) the diagnosis of patients presenting with chest pain complaints and an intermediate likelihood of CAD.
Particularly in these patients, a non-invasive test with a high specificity (to exclude CAD) is needed to allow optimal management of patients. Currently, MPI is used for this purpose, but the specificity of MPI is suboptimal (70%).
- Secondary outcomeN/A
- TimepointsN/A
- Trial web siteN/A
- statusinclusion stopped: follow-up
- CONTACT FOR PUBLIC QUERIESDr. J.J. Bax
- CONTACT for SCIENTIFIC QUERIESDr. J.J. Bax
- Sponsor/Initiator Leiden University Medical Center (LUMC), Department of Cardiology
- Funding
(Source(s) of Monetary or Material Support)
Dutch Heart Foundation (Nederlandse Hartstichting)
- PublicationsN/A
- Brief summaryN/A
- Main changes (audit trail)
- RECORD16-sep-2005 - 5-jan-2010


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