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MRI Flow Offset Correction Study


- candidate number19508
- NTR NumberNTR4865
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR19-sep-2014
- Secondary IDsNone available 
- Public TitleMRI Flow Offset Correction Study
- Scientific TitleIn-vivo validation of background offset correction in MRI phase contrast velocity acquisitions
- ACRONYM
- hypothesisTo validate in vivo the velocity offset correction method as published by Walker PG et al. (JMRI 3, 521 1993) such that it can assure velocity offsets < 0.6 cm/s at the ascending aorta and pulmonary artery for 2D through-plane phase contrast MRI velocity measurements at different centers and for different vendors.
- Healt Condition(s) or Problem(s) studiedMRI, Magnetic resonance imaging (MRI)
- Inclusion criteria- Informed consent
- Sinus rhythm at CMR examination
- 2D flow acquisitions by MRI at the aorta or pulmonary artery without spatial infolding artefacts.
- MRI acquisition on MRI system by Siemens: Magnetom Avanto, VB17 or newer 1.5 T systems such; for GE: Signa Excite (HDx 15M4) or newer as the Optima MR360; and for Philips: Achieva R2.6.3 or newer as the Ingenia.
- MRI flow acquisitions with the general accepted standard settings
- Exclusion criteria- Incapacitated adults.
- Lack of a phantom measurement within the protocol specifications.
- mec approval receivedyes
- multicenter trialyes
- randomisedno
- group[default]
- TypeSingle arm
- Studytypeobservational
- planned startdate 28-jul-2014
- planned closingdate1-mei-2015
- Target number of participants120
- InterventionsObservational study.
Seperate phantom measurements will be obtained after an in vivo clinical MRI scan.
- Primary outcomeThe primary study outcome parameter is the velocity offset in cm/s at the location of the aorta or pulmonary artery.
- Secondary outcome- To describe the offset error over the systems included in the study
- To test whether the static phantom offset corrections are valid, the difference between the velocity at the thorax wall and the phantom be assessed.
- The validity of offset corrections using higher order fitting, and the LPC filter.
- TimepointsThere will an analysis at the end of the inclusion periode, at about 1 year.
- Trial web site
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIESPhD M.B.M. Hofman
- CONTACT for SCIENTIFIC QUERIESPhD M.B.M. Hofman
- Sponsor/Initiator VU University Medical Center
- Funding
(Source(s) of Monetary or Material Support)
VU University Medical Center
- Publications
- Brief summary
- Main changes (audit trail)
- RECORD19-sep-2014 - 25-nov-2014


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