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The influence of nutrition on respiratory infections in children


- candidate number20896
- NTR NumberNTR4898
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR7-nov-2014
- Secondary IDsP14-39 METC Enschede
- Public TitleThe influence of nutrition on respiratory infections in children
- Scientific TitleThe influence of a dietary advice consisting of green vegetables, beef and whole dairy products on recurrent upper respiratory tract infections in children, a randomised controlled trial
- ACRONYM
- hypothesisA nutrient rich diet can improve immunological functions and reduce respiratory infections
- Healt Condition(s) or Problem(s) studiedChildren, Upper respiratory tract infection, Nutrition
- Inclusion criteria- age 1-4 years
- recurrent upper respiratory tract infections
- understanding of Dutch language by parents
- Exclusion criteria- immunological deficiencies
- cow's milk allergy
- disorder of intestinal absorption
- prophylactic use of antibiotics
- disorders requiring a special diet
- relevant congenital or anatomical abnormalities
- mec approval receivedyes
- multicenter trialyes
- randomisedyes
- masking/blindingSingle
- controlNot applicable
- groupParallel
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 1-jan-2015
- planned closingdate1-jan-2018
- Target number of participants120
- InterventionsA nutrient rich diet consisting of beef, green vegetables, whole milk and butter, in age appropriate portions
- Primary outcomeAverage number of days a month with a pediatrician diagnosed upper respiratory tract infection
- Secondary outcome- Immunological changes in bloodtests
- Parents' absence of work
- Use of antibiotics
- Cholesterol values
- Timepointst= 0, 3 and 6 months
- Trial web site
- statusplanned
- CONTACT FOR PUBLIC QUERIES E.J. Gaag, van der
- CONTACT for SCIENTIFIC QUERIES E.J. Gaag, van der
- Sponsor/Initiator Medisch Spectrum Twente, Ziekenhuisgroep Twente
- Funding
(Source(s) of Monetary or Material Support)
None
- PublicationsRecurrent Upper Respiratory Tract Infections in Children; The Influence of Green Vegetables, Beef, Whole Milk and Butter. Loes G. H. Ten Velde, Jolien Leegsma, Ellen J. Van der Gaag.
http://file.scirp.org/Html/11-2700861_37865.htm
- Brief summaryBackground: Immunological mechanism and dietary nutrients are important mediators in the health of children. In this intervention study a dietary advice is given to children between 1 and 6 years of age with recurrent respiratory tract infections. Could a change in nutrient intake result in an altered clinical outcome? Design: In this prospective cohort study 61 children were included and evaluated at a paediatric outpatient clinic. The control group consisted of 32 children included at an infant welfare centre. The patient group followed the dietary advice (green vegetables, beef, whole milk, full-fat butter) for three months, in which parents filled out their dietary intake and health status on a daily basis. A follow up form was filled out by the parents 3 months after completion of the study period. For statistical analysis the programme SPSS version 15.0 was used. Results: In the patient group there was a statistical significant reduction in days with a respiratory infection (15.7 to 11.5 days a month), subfebrile temperature days (1.9 to 0.5 days a month) and febrile temperature days (1.0 to 0.7 days a month) compared to the control group. Also, antibiotic use decreased significantly. No significant changes were measured in body mass index. Conclusions: A change of diet towards green vegetables, beef, whole milk and full-fat butter has positive health effects in children. This diet may work by adding nutrients to optimize immunological mechanisms. There were no adverse effects and it can be utilized by general pediatricians and general practitioners.
- Main changes (audit trail)
- RECORD7-nov-2014 - 27-dec-2014


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