Who are we?


Signup for

Online registration

Log in to register
your trial

Search a trial




van CCT (UK)

van CCT (UK)

Learning to eat with attention or knowledge: how does an intensive training program affect eating habits and the brain?

- candidate number21277
- NTR NumberNTR5025
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR5-jan-2015
- Secondary IDsNL43884.091.13 2013-188
- Public TitleLearning to eat with attention or knowledge: how does an intensive training program affect eating habits and the brain?
- Scientific TitleBreaking the habit: an explorative study on the neural correlates of mindful eating
- hypothesis
- Healt Condition(s) or Problem(s) studiedOvereating, Mindfulness
- Inclusion criteria- BMI: 19-35
- Age: 18-55 years old
- Right-handed
- Motivated to change their eating pattern, i.e. willing to participate actively in the training program & fulfill the homework requirements
- Exclusion criteria- Diabetes Mellitus
- (History of) clinically significant hepatic, cardiac, obstructive respiratory, renal, cerebrovascular, endocrine, metabolic or pulmonary disease
- Uncontrolled hypertension, defined as diastolic blood pressure at rest > 90 mmHg or systolic blood pressure at rest > 160 mmHg
- (History of) clinically significant neurological or psychiatric disorders, and current psychological treatment
- History of taste or smell impairments
- Use of neuroleptica or other psychotropic medication
- Deafness, blindness, or sensori-motor handicaps
- Drug or alcohol addiction in the past 6 months
- Inadequate command of Dutch language
- Eating disorders (Anorexia/Bulimia Nervosa, Binge Eating Disorder)
- Extreme restraint eating (i.e. score restraint eating ≥4 (females) or ≥ 3.6 (males) on the Dutch Eating Behavior Questionnaire)
- Current, strict dieting (i.e. specific diet and/or in treatment with dietitian)
- Changes in body weight > 5kg during the last 2 months
- Food allergy to one of the ingredients used in the food rewards
- Formerly/currently involved in MBSR or MBCT course
- Contra-indications for MRI:
o Metal objects or fragments in the body that cannot be taken out
o Active implants in the body
o Using medical plasters
o Epilepsy
o Previous head surgery
o Pregnancy
o Claustrophobia
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingSingle
- controlActive
- groupParallel
- Type[default]
- Studytypeintervention
- planned startdate 10-okt-2013
- planned closingdate1-apr-2017
- Target number of participants92
- Interventionsmindful eating training, educational cooking training
- Primary outcome- fMRI BOLD (prefrontal cortex) responses and performance (i.e. response times) for indicating the color of food words versus neutral words and for indicating the color of emotional words versus neutral words, as a measure of attentional bias/goal-directed control

- fMRI BOLD (striatal) responses and performance (i.e. response times) on targets following palatable food cues versus neutral food cues and on targets following high monetary reward cues versus low monetary reward cues, as a measure of reward cue sensitivity.

- fMRI BOLD correlations between prefrontal and striatal areas during resting state, as a measure of fronto-striatal connectivity, i.e. top-down control of the prefrontal cortex on striatal reward areas.

- Performance (i.e. number of button presses) for a devalued versus a still valued food outcome following selective satiation (i.e. outcome devaluation) as a measure of goal-directed behaviour.

- Performance (i.e. error rates) on trials following unexpected outcome during deterministic reversal learning, which enables the comparison of sensitivity to unexpected reward and sensitivity to unexpected punishment.

- Amount of food intake (kcal) following an acute stressor, as a measure of stress-induced habitual food intake.
- Secondary outcome- BMI (kg/m2), waist-hip ratio and scores on eating behavior questionnaires (both in terms of nutrients and behavior), as a measure of changed eating patterns.
- TimepointsDAY1 (intake)
DAY2 (testday 1 month pre-training)
DAY3 (testday 1 month post-training)
DAY4 (follow-up 1 year post-training)
- Trial web sitena
- status[default]
- Sponsor/Initiator Donders Institute for Brain, Cognition, and Behaviour, Centre for Cognition, Radboud University Nijmegen
- Funding
(Source(s) of Monetary or Material Support)
VENI, Axa, EFRO Esther
- Publicationsna
- Brief summaryna
- Main changes (audit trail)
- RECORD5-jan-2015 - 12-apr-2015

  • Indien u gegevens wilt toevoegen of veranderen, kunt u een mail sturen naar