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Train the sedentary brain: move smart to reduce the risk of dementia. Sub study: Alternating aerobic and strength exercise in APOEe4 carriers and non-carriers in early stage dementia: effects and dose-response relation.


- candidate number21737
- NTR NumberNTR5035
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR2-mrt-2015
- Secondary IDsNL51498.042.14 METc UMCG
- Public TitleTrain the sedentary brain: move smart to reduce the risk of dementia. Sub study: Alternating aerobic and strength exercise in APOEe4 carriers and non-carriers in early stage dementia: effects and dose-response relation.
- Scientific TitleTrain the sedentary brain: move smart to reduce the risk of dementia. Sub study: Alternating aerobic and strength exercise in APOEe4 carriers and non-carriers in early stage dementia: effects and dose-response relation.
- ACRONYM
- hypothesisA 6-month combined strength and aerobic training is feasible in patients with early-stage dementia and has positive effects on cognitive and physical functions, as well as mood, quality of life and activities of daily living. The association between physical activity and cognition is moderated by the presence of the ApoE4 allele.
- Healt Condition(s) or Problem(s) studiedDementia, Alzheimer, Cognitive decline, Physical activity, Physical activity
- Inclusion criteriaAge 65 years; diagnosis of dementia; visiting daycare at least three times a week; able to perform the Timed Up & Go Test with or without assistive device, and a Mini Mental State Examination score higher than 20.
- Exclusion criteriaWheelchair bound, severe cardiovascular problems that limit physical activity, brain trauma, epilepsy, progressive or terminal disease, severe depression, history of alcoholism, severe visual problems, severe auditory problems, problems with the Dutch language and mental incompetence.
- mec approval receivedyes
- multicenter trialyes
- randomisedyes
- masking/blindingSingle
- controlActive
- groupParallel
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 16-feb-2015
- planned closingdate1-dec-2017
- Target number of participants128
- InterventionsCombined strength and aerobic training with a duration of 6 months, 3 times a week for 30 minutes.
- Primary outcomeCognitive functioning: verbal and visual-spatial memory, working memory, executive functioning (set-shifting, response inhibition), attention and psychomotor speed.
- Secondary outcomePhysical fitness measured with performance-based tests, level of physical activity, ADLs, mood and quality of life
- TimepointsFull assessments at pretest, after 12 weeks and posttest (after 24 weeks). Short assessments after 6, 18 and 36 (follow-up) weeks.
- Trial web site
- statusplanned
- CONTACT FOR PUBLIC QUERIESMSc L.M.J. Sanders
- CONTACT for SCIENTIFIC QUERIESMSc L.M.J. Sanders
- Sponsor/Initiator University Medical Center Groningen (UMCG)
- Funding
(Source(s) of Monetary or Material Support)
ZON-MW, The Netherlands Organization for Health Research and Development
- Publications
- Brief summary
- Main changes (audit trail)18-apr-2015: titel wijziging.

Old: "Train the sedentary brain: move smart to reduce the risk of dementia."
New: "Train the sedentary brain: move smart to reduce the risk of dementia. Sub study: Alternating aerobic and strength exercise in APOEe4 carriers and non-carriers in early stage dementia: effects and dose-response relation."
- RECORD2-mrt-2015 - 18-apr-2015


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