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Minimally invasive autopsy (MIA): alternative for the conventional autopsy (CA)?


- candidate number21713
- NTR NumberNTR5072
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR23-feb-2015
- Secondary IDsMEC-2011-055 
- Public TitleMinimally invasive autopsy (MIA): alternative for the conventional autopsy (CA)?
- Scientific TitleMinimally invasive autopsy (MIA) in hospital setting opposed to conventional autopsy (CA); a validation study
- ACRONYM
- hypothesisMIA is a good alternative for the CA, with comparable diagnostic performance. It will lead to an increase in clinical autopsy rates, which have significantly decreased over the last decades in both academic and non-academic medical centers.
- Healt Condition(s) or Problem(s) studiedPost-mortem radiology, MRI-guided, Computed tomography, Stereotactic brain biopsy, Autopsy
- Inclusion criteriaDeceased adult patients, written informed consent from next of kin, availability of imaging equipments and technologists
- Exclusion criteriaforensic causes of death, known or suspected “high-risk” infected cadavers (hepatitis C, human immunodeficiency virus, tuberculosis), open abdominal wounds and body size too large for imaging equipment.
- mec approval receivedno
- multicenter trialno
- randomisedno
- group[default]
- TypeSingle arm
- Studytype[default]
- planned startdate 20-jan-2012
- planned closingdate
- Target number of participants100
- InterventionsWe performed MIA followed by CA the following day. Both the MIA investigators and CA pathologists who performed the autopsy received the same clinical information and were blinded to each other's findings.
- Primary outcomeAgreement between MIA and CA for cause of death and sensitivity and specificity of major and overall findings
- Secondary outcome- Comparing CA and MIA of the brain.
- Estimating the amount of information lost by MIA, compared to the CA and finding out if the expected increase of autopsies performed compensates for this loss.
- Comparing costs of the MIA versus CA.
- TimepointsNot appicable
- Trial web site
- statusstopped: trial finished
- CONTACT FOR PUBLIC QUERIESProf. Dr. J.W. Oosterhuis
- CONTACT for SCIENTIFIC QUERIESProf. Dr. J.W. Oosterhuis
- Sponsor/Initiator Erasmus Medical Center
- Funding
(Source(s) of Monetary or Material Support)
Erasmus Medical Center, Stichting Coolsingel, KWF Kankerbestrijding
- Publications
- Brief summary
- Main changes (audit trail)
- RECORD23-feb-2015 - 20-apr-2015


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