search  
 


Home

Who are we?

Why
register?


Signup for
registration


Online registration

Log in to register
your trial


Search a trial

NRT en CCMO

Contact

NEDERLANDS





MetaRegister
van CCT (UK)


ISRCTN-Register
van CCT (UK)


Heavy water method for protein synthesis


- candidate number21796
- NTR NumberNTR5099
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR12-mrt-2015
- Secondary IDsMETC 15-3-003 NL52517.068.15
- Public TitleHeavy water method for protein synthesis
- Scientific TitleThe efficacy and applicability of oral 2H2O dosing to measure in vivo human skeletal muscle protein synthesis
- ACRONYMD2O_PILOT
- hypothesis
- Healt Condition(s) or Problem(s) studied
- Inclusion criteria Healthy males
Age between 18 and 35 y
BMI between 18.5 and 30 kg/m2
Moderate level of physical activity (exercising 2-4 hours per week)
- Exclusion criteria Celiac disease Lactose intolerance Smoking Diabetes Cancer
Cardiovascular Disease
Donated blood within the last 3 months
Diagnosed GI tract diseases
Arthritic conditions
A history of neuromuscular problems
Any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).
- mec approval receivedyes
- multicenter trialno
- randomisedno
- groupCrossover
- TypeSingle arm
- Studytypeintervention
- planned startdate 1-mei-2015
- planned closingdate1-mei-2018
- Target number of participants12
- InterventionsSingle-legged resistance exercise training
- Primary outcomeMuscle protein synthesis (MPS) rates
- Secondary outcomePlasma free L-[2,3,3,3-2H4]-alanine enrichment (expressed as MPE)
Saliva 2H2O enrichment (Expressed as APE)
- TimepointsMuscle Biopsies on day 4 and day 7 (2 each day)
Blood and saliva samples on day 2 (4 each) and on days 3, 4, 5, 6, 7 (one each).
- Trial web site
- statusplanned
- CONTACT FOR PUBLIC QUERIESMSc. A. Holwerda
- CONTACT for SCIENTIFIC QUERIESMSc. A. Holwerda
- Sponsor/Initiator Maastricht University
- Funding
(Source(s) of Monetary or Material Support)
Maastricht University
- Publications
- Brief summary
- Main changes (audit trail)
- RECORD12-mrt-2015 - 13-apr-2016


  • Indien u gegevens wilt toevoegen of veranderen, kunt u een mail sturen naar nederlands@trialregister.nl