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van CCT (UK)

van CCT (UK)

Difference in digestion and absorption of milk proteins

- candidate number22291
- NTR NumberNTR5242
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR3-jun-2015
- Secondary IDsNL52798.068.15 
- Public TitleDifference in digestion and absorption of milk proteins
- Scientific TitleThe digestion and absorption kinetics of micellar casein versus caseinate in healthy young men
- hypothesisThe following hypothesis will be investigated:
- Casein ingested as calcium-caseinate results in a more rapid digestion and absorption, and subsequent whole body net protein balance, as compared to the ingestion of micellar casein.
- The ingestion of a calcium-caseinate solution will result in a more rapid digestion and absorption, and subsequent whole body net protein balance, as compared to the ingestion of calcium-caseinate fibers.
- Healt Condition(s) or Problem(s) studiedMilk proteins, Protein digestion
- Inclusion criteria- Males
- Aged between 18-35 years
- Healthy, recreationally active (participating in recreational sports activities 3 times per week)
- BMI < 25 kg/m2
- No physical limitations (i.e. able to perform all activities associated with daily living in an independent manner).
- Exclusion criteria- Female
- Smoking
- Allergies to milk proteins
- Musculoskeletal disorders
- Use of any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescribed acne medications).
- Participation in any structured regular exercise program
- Chronic use of gastric acid suppressing medication or anti-coagulants - Unstable weight over the last three months - Pathologies of the gastrointestinal tract
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingNone
- controlActive
- groupParallel
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 1-sep-2015
- planned closingdate13-feb-2017
- Target number of participants45
- Interventionseach subject will participate in one trial, randomly assigned. Intervention consists of the ingestion of an intrinsically labeled protein supplement: micellar casein, calcium caseinate, or caseinate fibers, whereafter regular blood samples are taken.
- Primary outcomeexogenous phenylalanine appearance rates
- Secondary outcomewhole-body protein synthesis plasma insulin, glucose and amino acid concentrations
- Timepointsblood samples will be taken immediately before ingestion of the protein supplement (t=0), and at timepoints: 15, 30, 45, 60, 90, 120, 150, 180, 210, 240, 300 and 360 min.
- Trial web site
- statusstopped: trial finished
- CONTACT FOR PUBLIC QUERIESPostdoctoral research fellow Milou Beelen
- CONTACT for SCIENTIFIC QUERIESPostdoctoral research fellow Milou Beelen
- Sponsor/Initiator Maastricht University
- Funding
(Source(s) of Monetary or Material Support)
Maastricht University
- Publications
- Brief summary
- Main changes (audit trail)
- RECORD3-jun-2015 - 11-jan-2018

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