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Long-term effects of arthroscopic meniscal allograft transplantation: clinical and subjective evaluation 5 years postoperative a prospective cohort study


- candidate number22381
- NTR NumberNTR5277
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR24-jun-2015
- Secondary IDsNL 54018.098.15 METC Zuidwest Holland
- Public TitleLong-term effects of arthroscopic meniscal allograft transplantation: clinical and subjective evaluation 5 years postoperative a prospective cohort study
- Scientific TitleLong-term effects of meniscal transplantation: clinical and subjective evaluation
- ACRONYMAMAT PCS
- hypothesisClinical subjective evaluation of meniscal allograft transplantation. Subjective assessments of the patients and the difference in amount of osteoarthritis in knee joint 5-years postoperative. Function of knee will be improved, patients satisfaction will be higher and osteoarthritis will be reduced.
- Healt Condition(s) or Problem(s) studiedArthrosis, Tibial meniscus
- Inclusion criteriaMeniscal allograft transplantation in the period of 2010 till 2013
- Exclusion criteriaRevision of meniscal transplantation
Failure of the graft
Pregnancy
- mec approval receivedno
- multicenter trialno
- randomisedno
- group[default]
- TypeSingle arm
- Studytypeobservational
- planned startdate 1-aug-2015
- planned closingdate30-jun-2017
- Target number of participants26
- InterventionsMeniscal allograft transplantation - 5 year follow up. Using DEXA-scan, skeletal scintigraphy, MRI and questionnaires.
- Primary outcomeImproved clinical subjective evaluation of meniscal allograft transplantation
- Secondary outcomeImproved function of knee, increased patient satisfaction and difference of amount of radiological osteoarthritis
- Timepointsone time point, 5 years postoperative
- Trial web site
- statusinclusion stopped: follow-up
- CONTACT FOR PUBLIC QUERIESDrs. B.J.W. Thomassen
- CONTACT for SCIENTIFIC QUERIESDrs. B.J.W. Thomassen
- Sponsor/Initiator Medical Center Haaglanden, Bronovo Hospital
- Funding
(Source(s) of Monetary or Material Support)
MCH wetenschapsfonds
- Publications
- Brief summaryMoving without pain and discomfort is possible due to the menisci in the knee. An injury at the menisci can lead to disability and pain. A meniscectomy can be a solution for meniscal injuries. However due to the increased contact stresses and peak stresses on the cartilage surfaces, the risk of osteoarthritis increases after this treatment. For young patients with a post-meniscectomized, symptomatic knee a meniscal allograft transplantation can result in less post-meniscectomized symptoms including swelling, loss of function and pain. In order to assess the benefits of this transplantation, a lot of research has been done. Nonetheless it is not clear whether MAT can prevent degenerative changes and pain in the knee. Therefore we will perform a DEXA-scan, skeletal scintigraphy and MRI for objective assessment and the subjects will have to fill in questionnaires for subjective assessment.
- Main changes (audit trail)
- RECORD24-jun-2015 - 18-aug-2015


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