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MCCT study (Maastricht COPD CT study)


- candidate number21949
- NTR NumberNTR5318
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR15-apr-2015
- Secondary IDsNL49554.068.14 
- Public TitleMCCT study (Maastricht COPD CT study)
- Scientific TitleLow dose-CT for differentiation between AECOPD and pneumonia. An effective tool for diagnosis of radiological pneumonia?
- ACRONYM
- hypothesis
- Healt Condition(s) or Problem(s) studiedAcute exacerbation of COPD, Pneumonia
- Inclusion criteria* Adults, either sex, older than 40 years of age
* Smoking history of 10 Pack Years or more
* Diagnosis of COPD stages I-IV, class A-D, as defined by the Global initiative for chronic Obstructive Lung Disease (GOLD)
* Doctor's diagnosis of AECOPD (clinical presentation of a patient complaining of an acute change of symptoms that is beyond normal day-to-day variation - baseline dyspnoea, cough and/or sputum production)
* Patients must sign and date an informed consent prior to inclusion in the study
- Exclusion criteria* Progressively fatal disease, or life expectancy <= 6 months
* Women who are breast-feeding or are pregnant
* Patients with mental conditions rendering them unable to understand the nature, scope, and possible consequences of the study
* Patients participating in an intervention study which influences outcomes
* Un-ability to lie flat for the performance of CT-scan
- mec approval receivedyes
- multicenter trialno
- randomisedno
- group[default]
- Type[default]
- Studytypeobservational
- planned startdate 1-mei-2015
- planned closingdate1-jan-2017
- Target number of participants202
- InterventionsCT-scan (once) and 3 times blood sample
- Primary outcomeFrequency of radiological pneumonia in exacerbating COPD patients as analysed by low dose-CT
- Secondary outcome* Clinical and/or biochemical predictors (PCT) for radiological pneumonia in COPD patients proven by low dose-CT
* Pulmonary pathology evidenced by low dose-CT
* Phenotype COPD exacerbations based on outcomes of low dose-CT
- TimepointsBaseline (admission to the hospital)
Day 3 (blood sample)
Follow-up (check medical records at t=30 and t=90)
- Trial web site
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIES Dionne Braeken
- CONTACT for SCIENTIFIC QUERIES Dionne Braeken
- Sponsor/Initiator Maastricht University Medical Center (MUMC+)
- Funding
(Source(s) of Monetary or Material Support)
Maastricht University Medical Center (MUMC+), Thermo Fisher Scientific
- Publications
- Brief summary
- Main changes (audit trail)
- RECORD15-apr-2015 - 14-feb-2016


  • Indien u gegevens wilt toevoegen of veranderen, kunt u een mail sturen naar nederlands@trialregister.nl