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The effect of arabinose on glycaemic response and glucose absorption


- candidate number21953
- NTR NumberNTR5319
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR15-apr-2015
- Secondary IDsNL51738.081.15 / 15/01 ABR / METC-WU
- Public TitleThe effect of arabinose on glycaemic response and glucose absorption
- Scientific TitleThe effect of arabinose on glycaemic response and glucose absorption
- ACRONYMAra-study
- hypothesisThe main objective is to quantify and compare sucrose hydrolysis by sucrase and glucose absorption and glycaemic response of added arabinose to liquid and solid sucrose containing food products.
- Healt Condition(s) or Problem(s) studiedEating behaviour, Obesity, Diabetes Mellitus, Overweight
- Inclusion criteria- Male
- 18-35 Years old while signing the informed consent
- Good Dutch speaking, writing, understanding
- Healthy: as judged by the subject
- BMI: 18.5-25 kg/m2
- Stable body weight, i.e. no reported weight loss or weight gain of > 5 kg in the two months prior to the screening session
- Normal fasting glucose concentration <6.1 mmol/L
- Normal hemoglobine (Hb) concentration >8.5 mmol/L
- Exclusion criteria- Allergy, intolerance or oversensitivity for the food products under study
- Having a history of medical or surgical events that may affect the study outcome
- Having reported gastro-intestinal problems
- Medical drug use that may affect the study outcome
- Current antibiotics usage or in the two months prior to the screening session
- Not willing to eat muffins or to drink fruit-based drinks - Being a vegetarian (not willing to eat meat)
- Use of dietary supplements that may affect the study outcome
- Currently using a slimming or medically prescribed diet or having used one in the two months prior to the screening session
- Excessive alcohol consumption (>21 glasses/week on average)
- Elite athletes, i.e. exercise > 7h/week vigorously
- Planning to change physical activity pattern during the study period
- Having blood vessels that are too difficult for inserting a cannula, as judged by the study nurse
- Recent blood donation (<1 month prior to day 1 of the study)
- Not willing to donate blood during the study
- Not having a general practitioner
- Being an employee of Wageningen University, department of Human Nutrition
- Current participation in other research
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingDouble
- controlPlacebo
- groupCrossover
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 29-apr-2015
- planned closingdate11-jun-2015
- Target number of participants18
- Interventions1) Control drink; 2) Xylose drink; 3) Arabinose drink; 4) Control muffin; and 5) Arabinose muffin
- Primary outcomePlasma glucose and insulin levels
- Secondary outcome13C levels in exhaled breath, subsequent ad libitum food intake, appetite and gastro-intestinal comfort
- TimepointsEvery subject will visit the laboratory 7 times:
1. For an information meeting;
2. For a screening meeting;
3. 5 testsessions with in each session:
A. Plasma glucose and insulin levels and breath sample collection: 2 times before start of the treatment, and at 15, 30, 45, 60, 90, 120, 150, and 180 minutes after start of the treatment.
B. VAS questionnaire: Directly before, and at 15, 30, 45, 60, 75, 90, 120, 150, 180, 210, 240, and 270 minutes after start of the treatment;
C. Ad libitum test meal at 240 minutes after start of the treatment;
D. Gastro-intestinal comfort directly before and at 180 and 270 minutes after start of the treatment.
- Trial web site
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIES Korrie Pol
- CONTACT for SCIENTIFIC QUERIES Monica Mars
- Sponsor/Initiator Wageningen University (WUR)
- Funding
(Source(s) of Monetary or Material Support)
Cosun
- Publications
- Brief summary
- Main changes (audit trail)
- RECORD15-apr-2015 - 24-aug-2015


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