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CPMQ study


- candidate number22863
- NTR NumberNTR5414
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR11-sep-2015
- Secondary IDsP15.155 Commissie Medische Ethiek van het Leids Universitair Medisch Centrum, Leiden.
- Public TitleCPMQ study
- Scientific TitleCPMQ study: optimization of the conditioned pain modulation protocol using the q-sense.
- ACRONYMCPMQ
- hypothesisThe q-sense device will induce an equal conditioned pain modulation effect as the standard conditioning stimulus: cold water immersion.

Ipsilateral and contralateral conditioning will elicit equal conditioning pain modulation effects.
- Healt Condition(s) or Problem(s) studiedCentral neuropathic pain, Chronic pain, Endogenous pain modulation
- Inclusion criteriaHealthy male volunteers, aged 18 - 35, right handed.
- Exclusion criteriaObesity (BMI > 30 kg/m2);
History of chronic alcohol or illicit drug use;
History of illness, condition or medication use that, in the opinion of the investigator, might interfere with participation, or could confound the result;
Inability to understand the study information or give oral and written consent.
- mec approval receivedyes
- multicenter trialno
- randomisedno
- groupCrossover
- TypeSingle arm
- Studytypeintervention
- planned startdate 1-sep-2015
- planned closingdate30-nov-2015
- Target number of participants20
- InterventionsThermal pain testing using the conditioned pain modulation (CPM) paradigm:
1)using the q-sense
2)using water of 6 degrees Celsius
- Primary outcomeThe degree of CPM of q-sense vs cold water immersion: CPM is defined as the difference in pain intensity scored by the subject on a electronic visual analogue scale (eVAS) between non-conditioned and conditioned stimuli. We will evaluate the difference between CPM by the q-sense and CPM by cold water immersion.
- Secondary outcomeThe degree of CPM by placing the conditioning stimulus of the ipsilateral or contralateral leg.
- Timepointsn.a.
- Trial web site
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIES L.C.J. Oudejans
- CONTACT for SCIENTIFIC QUERIES L.C.J. Oudejans
- Sponsor/Initiator Leiden University Medical Center (LUMC)
- Funding
(Source(s) of Monetary or Material Support)
Leiden University Medical Center (LUMC)
- Publications
- Brief summaryConditioned pain modulation (CPM) is form of endogenous analgesia that is decreased in patients with chronic pain. The CPM paradigm is often used in experiments to determine whether endogenous analgesia of a group of patients is different from healthy subjects. However, the methods used differs between research groups. The q-sense device has been developed to measure CPM by using a thermal conditioning probe and to be able to compare studies. We will compare the ability of the q-sense to induce CPM with the most commonly used method to induce CPM so far: cold water immersion. Furthermore, we will compare ipsilateral with contralateral conditioning.
- Main changes (audit trail)
- RECORD11-sep-2015 - 28-okt-2015


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