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Train the sedentary brain: move smart. The cognitive benefits of an interactive cycling training in APOEe4 carriers and non-carriers in early stage dementia


- candidate number22953
- NTR NumberNTR5581
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR7-okt-2015
- Secondary IDs52581.091.15// 20115-1857 NL//METc
- Public TitleTrain the sedentary brain: move smart. The cognitive benefits of an interactive cycling training in APOEe4 carriers and non-carriers in early stage dementia
- Scientific TitleTrain the sedentary brain: move smart. The cognitive benefits of an interactive cycling training in APOEe4 carriers and non-carriers in early stage dementia
- ACRONYM
- hypothesisA 3-month interactive cycling training is feasible and leads to improved executive functioning and physical fitness in early stage dementia patients. The association between physical activity and cognition is moderated by the presence of the ApoE4 allele.
- Healt Condition(s) or Problem(s) studiedDementia, Alzheimer, Cognitive decline, Physical functioning
- Inclusion criteriaAge > 60 years; diagnosis of dementia; Mini Mental State Examination score higher than 20; having insufficient physical activity according to the ACSM guideline for older adults, maximum of 30 minutes five days a week moderate intensity
- Exclusion criteriaWheelchair bound, use of dementia targeted nutritional supplements (e.g. Souvenaird) within the last three months, severe cardiovascular problems that limit physical activity, brain trauma, epilepsy, progressive or terminal disease, severe depression, history of alcoholism, severe visual problems, severe auditory problems, problems with the Dutch language and mental incompetence
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingSingle
- controlActive
- groupParallel
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 1-sep-2015
- planned closingdate31-dec-2017
- Target number of participants171
- InterventionsWithin the study, three interventions are provided: (1) Interactive aerobic stationary cycle training, (2) Aerobic stationary cycle training, (3) Non-aerobic stretching and toning exercises. Forty-five minute sessions were offered 3 times per week for a period of 12 weeks. The interactive cycling training is a dual-task training in which participants follow a route on a screen in front of the bike and conduct simple cognitive tasks.
- Primary outcomeExecutive functioning (set-shifting, response inhibition)
- Secondary outcomeVerbal and visual-spatial memory, working memory, attention, psychomotor speed, physical fitness, levels of physical activity, quality of life.
- TimepointsFull assessments at pretest, after 12 weeks and at follow up (24 weeks). Short assessments after 6 weeks.
- Trial web site
- status[default]
- CONTACT FOR PUBLIC QUERIESDrs. Esther G.A. Karssemeijer
- CONTACT for SCIENTIFIC QUERIESDrs. Esther G.A. Karssemeijer
- Sponsor/Initiator Radboud University Medical Center Nijmegen
- Funding
(Source(s) of Monetary or Material Support)
ZON-MW, The Netherlands Organization for Health Research and Development
- Publications
- Brief summaryThere is no cure for dementia. Non pharmacological interventions are needed. The aim of this study is to investigate the cognitive effects of an interactive cycling training in early stage dementia patients, compared to an aerobic stationary cycling training and an active control group.
- Main changes (audit trail)12-apr-2017:
Outcome added:
Frailty (Evaluative Frailty Index for Physical Activity)
- RECORD7-okt-2015 - 12-apr-2017


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