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Sick of sitting?


- candidate number23699
- NTR NumberNTR5723
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR1-feb-2016
- Secondary IDs2015.053 METc VUmc
- Public TitleSick of sitting?
- Scientific TitleSick of sitting: exerimental evidence
- ACRONYMSOS
- hypothesisIn normal weight and overweight/obese young males we expect that - when compared to a single bout of prolonged sitting:
(1) sitting on a stability ball will attenuate cardiometabolic health effects;
(2) 10-min standing interruptions will not attenuate cardiometabolic health effects.
- Healt Condition(s) or Problem(s) studiedSitting
- Inclusion criteria- Apparently healthy normal weight or overweight/obese males;
- Aged 18-20 years;
- Dutch or English speaking;
- Signed informed consent from the participant (age 18-19) or the participant and both parents (age 17).
- Exclusion criteria- Major acute illness/injury;
- Having diabetes mellitus type II according to the International Diabetes Federation;
- Physical problems that may limit the ability to perform the experiment (i.e. the standing interruptions or sitting on a stability ball).
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingNone
- controlActive
- groupCrossover
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 2-mrt-2015
- planned closingdate30-dec-2016
- Target number of participants40
- InterventionsAll included young males will undergo three experimental conditions, with a one-week washout period in between conditions:
I. Sitting only (i.e. on a chair with back support; control condition): participants will remain seated for 5 consecutive hours;
II. Sitting (on a chair with back support) and hourly 10-min standing interruptions: participants will stand for 10-min, using a sit-stand desk before returning to the seated position for 50 minutes. This procedure will be repeated 4 times (i.e. first hour is included to obtain a steady-state, with no standing interruption);
III. Sitting on a stability ball (i.e. without back support): participants will sit on a stability ball (i.e. without back support) for 5 consecutive hours.
- Primary outcomeThe main outcomes of this study are plasma levels of C-peptide, glucose, triglycerides, high-sensitive C-reactive protein (hs-CRP) and saliva levels of cortisol.
- Secondary outcomeSecondary outcomes of this study are functioning of the autonomic nervous system, sleep-wake patterns, attention/concentration and mood.
- TimepointsPlasma levels of C-peptide, glucose, triglycerides, hs-CRP will be collected hourly (i.e. 6 blood samples); saliva will be collected at baseline and at the end of the experimental days.
- Trial web site
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIES Teatske Altenburg
- CONTACT for SCIENTIFIC QUERIES Teatske Altenburg
- Sponsor/Initiator EMGO Institute, VU University Medical Center
- Funding
(Source(s) of Monetary or Material Support)
ZON-MW, The Netherlands Organization for Health Research and Development
- PublicationsAltenburg TM, Rotteveel J, Dunstan DW, Salmon J, Chinapaw MJM. The effect of interrupting prolonged sitting time with short, hourly, moderate-intensity cycling bouts on cardiometabolic risk factors in healthy, young adults. J Appl Physiol. 2013 Dec;115(12):17516.
- Brief summary
- Main changes (audit trail)
- RECORD1-feb-2016 - 2-mei-2016


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