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Dual energy CT for comprehensive cardiac imaging in patients suspected of coronary artery disease


- candidate number23951
- NTR NumberNTR5749
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR11-feb-2016
- Secondary IDsABR 53631 
- Public TitleDual energy CT for comprehensive cardiac imaging in patients suspected of coronary artery disease
- Scientific TitleDual energy CT for comprehensive cardiac imaging in patients suspected of coronary artery disease
- ACRONYM-
- hypothesisThe aim of this study is to validate a new CT technique (dual energy CT) in the ability to detect myocardial perfusion defects in patients suspected of having coronary artery disease. A combination of CT angiography and stress dual energy will be compared to gold standard diagnosis, SPECT and invasive coronary angiography.
- Healt Condition(s) or Problem(s) studiedCoronary artery disease, Dual energy CT
- Inclusion criteria Stable angina pectoris
Nuclear MPI within the last 60 days
Scheduled for ICA
Patients must provide consent in writing after proper education and discussion with the treating physician and/or research physician
50 years or older
- Exclusion criteria Cardiac rhythm other than sinus
Second or third degree atrioventricular block
Prolonged QT-time
Sick-sinus syndrome
Asthma or chronic obstructive pulmonary disease
Contraindications for iodine contrast
Thyroid gland disorders
Renal insufficiency (eGFR < 50 ml/min)
Rest heart > 65 bpm and contraindications for beta-blocker
Severe arterial hypertension (>220/120 mmHg)
Severe arterial hypotension (<80/40 mmHg)
Unable to stay in a supine position
Morbidly obese (Body mass index >35)
Severe physical deterioration due to concomitant illness
Language barrier
Acute coronary syndrome
Pregnancy
Claustrophobia
Using of persantin, theophylline, digoxin or verapamil, if temporarily stopping (48h) is not possible
Contraindications for CTA: presence of pacemaker or ICD leads, AF, pregnancy, BMI >35 kg/m2, prosthetic heart valve
Previously documented myocardial infarction/PCI/CABG
- mec approval receivedno
- multicenter trialno
- randomisedno
- group[default]
- Type[default]
- Studytype[default]
- planned startdate 1-mrt-2016
- planned closingdate31-mrt-2017
- Target number of participants50
- InterventionsDual energy CT scan and CT angiography
- Primary outcomeThe diagnostic accuracy of the rest coronary CT angiography in combination with stress dual energy CT in comparison to SPECT and invasive coronary angiography in patients with a intermediate to high risk of coronary artery disease.
- Secondary outcomeDiagnostic accuracy of myocardial ischemia detection using DECT in comparison to SPECT ischemia detection in patients with a intermediate to high risk of coronary artery disease, radiation dose.
- TimepointsNot applicable
- Trial web site-
- statusplanned
- CONTACT FOR PUBLIC QUERIESMD. PhD. R. Vliegenthart
- CONTACT for SCIENTIFIC QUERIESMD. PhD. R. Vliegenthart
- Sponsor/Initiator University Medical Center Groningen (UMCG)
- Funding
(Source(s) of Monetary or Material Support)
NWO Veni
- Publications-
- Brief summaryThe purpose of this study is to validate a comprehensive CT protocol to determine hemodynamically significant coronary artery disease. Combined DECT and CT angiography could provide a one-stop shop in cardiac imaging in the future. The diagnostic accuracy of DECT plus CT angiography will be determined in comparison to gold standard, SPECT and ICA. This proposal will provide crucial data evaluating this potential. The disadvantages of this study are the radiation dose and the administration of contrast agents and beta-blocker. In accordance with limited reports so far, we determined that the radiation burden for comprehensive cardiac CT imaging will not exceed 10 mSv for each individual patient, which can be checked real time during the CT examination. Because of the administration of contrast agent, patients with a poor renal function (eGFR< 50 ml/min) and iodine allergy will be excluded. Patients with healthy renal function are not expected to have negative effects due to the contrast administration. The scans will be made on a third generation dual source scanner (Force, Siemens Medical Systems, Forchheim, Germany).
- Main changes (audit trail)
- RECORD11-feb-2016 - 22-mei-2016


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