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Brain changes as a consequence of blindness in one half of the visual field


- candidate number23983
- NTR NumberNTR5752
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR17-feb-2016
- Secondary IDsNL55973.042.15 CCMO-register
- Public TitleBrain changes as a consequence of blindness in one half of the visual field
- Scientific TitleNeuroplasticitiy in homonymous hemianopia: functional and structural brain changes underlying residual and compensatory perceptual behaviour
- ACRONYMNeuroplasticity in homonymous hemianopia
- hypothesisWe expect to find adaptive auditory and visual processing (optimised residual and risen compensatory perceptual performance) as a consequence of homonymous hemianopia. Additionally, we hypothesise these changes to be reflected in sustained functional and structural changes on the cortical level. More specifically, we expect a) remapped visual field representations in the visual cortex, b) structural changes in the visual system (i.e. cortical thickness and white matter tracts), c) changes in cortical representations of auditory space, and d) changes in functional connectivity maps.
- Healt Condition(s) or Problem(s) studiedHomonymous hemianopia, Post chiasmatic cerebral accident
- Inclusion criteriaParticipants with hemianopia:
- have signed written consent
- age older than 18
- homonymous hemianopia due to post chiasmic CVA stable ophthalmologic conditions

Controls:
- have signed written consent age older than 18
- subjectively healthy
- Exclusion criteriaParticipants with hemianopia:
- visual neglect
- visual field defect due to condition other than post chiasmic CVA clinical eye conditions
- hearing impairments
- macular sparing

Controls:
- visual impairments
- auditory impairments
- mec approval receivedno
- multicenter trialno
- randomisedno
- group[default]
- Type[default]
- Studytypeobservational
- planned startdate 1-mrt-2016
- planned closingdate1-mrt-2019
- Target number of participants40
- Interventionsauditory and visual functioning tests (f)MRI measurements
- Primary outcomescores on visual and auditory functional tests, cortical activation and functional connectivity during visual and auditory processing, cortical and retinal nerve thickness and white matter tracts of all individual participants.
- Secondary outcomevisual evoked potentials, outcomes of a standard questionnaire (to determine in-/exclusion), eye-tracking movements during visual tasks.
- Timepointsnot applicable, no longitudinal design
- Trial web sitenot applicable
- statusplanned
- CONTACT FOR PUBLIC QUERIES H.N. Halbertsma
- CONTACT for SCIENTIFIC QUERIES H.N. Halbertsma
- Sponsor/Initiator University Medical Center Groningen (UMCG)
- Funding
(Source(s) of Monetary or Material Support)
BCN-BRAIN, University Medical Center Groningen
- Publicationsnot applicable
- Brief summaryEven though there is increasing interest in the reorganisation of the brain after vision loss, systemic investigation of neuroplasticity in patients with homonymous hemianopia (HH), the complete loss of one side of the visual field, is still very rare. Better understanding of this unchartered field has tremendous potential for the development or neuroscientifically-motivated rehabilitation techniques. For that reason and with this project, I want to get insight into whether and how both the visual and the auditory system reorganise after acquiring HH. More specifically, I want to investigate adaptive auditory and visual processing (optimised residual and risen compensatory perceptual performance) of patients with HH and I expect this to be reflected in cortical reorganisation at both a structural and a functional level. For this purpose psychophysical tests will be performed and cortical plasticity will be assed by (f)MRI using a combination of a novel techniques (i.e. population receptive field modelling, connective field mapping and cortical thickness comparisons). In this way, the impact of homonymous visual field defects on perceptual processing can be investigated and, subsequently, the degree of optimised residual and compensatory perceptual behaviour can be correlated with structural and functional cortical plasticity. This provides us with new quantitative knowledge about changes in cortical structure, visual and auditory networks and maps in HH close to the level of neuronal populations the level that is most critical for understanding the relationship between neural computations, behaviour and perception, which could eventually lead to systematic training tools that will improve the reorganisation.
- Main changes (audit trail)
- RECORD17-feb-2016 - 22-mei-2016


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