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Remission induction in early rheumatoid arthritis.


- candidate number1927
- NTR NumberNTR578
- ISRCTNIncomplete info for ISRCTN
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR12-jan-2006
- Secondary IDsN/A 
- Public TitleRemission induction in early rheumatoid arthritis.
- Scientific TitleRemission induction in early rheumatoid arthritis.
- ACRONYMN/A
- hypothesisEarly and aggressive treatment of rheumatoid arthritis according to a strict treatment protocol results in a 70% remission of the disease within 2 years.
- Healt Condition(s) or Problem(s) studiedRheumatoid arthritis
- Inclusion criteria1. RA according to ACR1987 criteria;
2. diagnosis RA <3 months;
3. age >18;
4. no prior DMARD use;
5. DAS 28 > 3.2 and/or erosions.
- Exclusion criteriaPregnancy/pregnancy wish.
- mec approval receivedyes
- multicenter trialyes
- randomisedno
- group[default]
- TypeSingle arm
- Studytypeintervention
- planned startdate 9-jan-2006
- planned closingdate9-jan-2008
- Target number of participants200
- InterventionsTight control of disease activity by a strict treatment scheme and strictly defined decision moments for treatment changes.
- Primary outcomePercentage of patients reaching DAS28<2.6.
- Secondary outcome1. Radiographic changes;
2. Percentage of patients staying in remission;
3. Percentage of patients staying in remission after discontinuation of anti-YNF medication.
- TimepointsN/A
- Trial web siteN/A
- statusstopped: trial finished
- CONTACT FOR PUBLIC QUERIESDr. H.H. Kuper
- CONTACT for SCIENTIFIC QUERIESDr. H.H. Kuper
- Sponsor/Initiator
- Funding
(Source(s) of Monetary or Material Support)
- PublicationsN/A
- Brief summaryPatients with recent onset RA are treated according to a tight step up medication scheme. Aim of treatment is to reach clinical remission of the disease as soon as possible, DAS 28 < 2.6. Introduction of anti-TNF medication is possible after the use of 2 DMARDs, according to the present Dutch regulations for the use of anti-TNF in clinical practice. If remission is reached with the use of anti-TNF and the disease stays in remission for 6 months, de anti-TNF dose will reduced and in the case of persisting remission be stopped. Radiographic damge and disease activity will be monitored regularly.
- Main changes (audit trail)
- RECORD12-jan-2006 - 23-apr-2008


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