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Het effect van deoxycholzuur op insuline


- candidate number24321
- NTR NumberNTR5849
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR4-mei-2016
- Secondary IDsNL44479.018.13 METC2013_096
- Public TitleHet effect van deoxycholzuur op insuline
- Scientific TitleEffects of deoxycholic acid supplementation on insulin: role for the transmembrane G coupled protein receptor TGR5
- ACRONYMDCA
- hypothesisDeoxycholic acid might augment the postprandial insulin response through stimulation of TGR5 on enteroendocrine cells and beta cells.
- Healt Condition(s) or Problem(s) studiedDiabetes Mellitus Type 2 (DM type II), Obesity
- Inclusion criteriahealthy lean male age 18+
- Exclusion criteriamedication use
history of gastrointestinal surgery or gallstones
metabolic disease
- mec approval receivedyes
- multicenter trialno
- randomisedno
- groupCrossover
- TypeSingle arm
- Studytypeintervention
- planned startdate 5-sep-2013
- planned closingdate
- Target number of participants10
- Interventionssingle administration of 750 mg deoxycholate
- Primary outcomepostprandial insulin and bile acid concentrations in plasma
- Secondary outcomepostprandial resting energy expenditure and glucose concentrations.
- Timepoints0, 15, 30, 45, 60, 75, 90, 120, 150, 180 and 240 minutes
- Trial web site
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIESMD. M.R. Soeters
- CONTACT for SCIENTIFIC QUERIESMD. M.R. Soeters
- Sponsor/Initiator Academic Medical Center (AMC), Amsterdam
- Funding
(Source(s) of Monetary or Material Support)
Diabetes Fonds
- Publications
- Brief summary
- Main changes (audit trail)
- RECORD4-mei-2016 - 1-jul-2016


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