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van CCT (UK)


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van CCT (UK)


The effect of blood flow restriction with and without resistance exercise on muscle protein synthesis


- candidate number24542
- NTR NumberNTR5914
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR30-jun-2016
- Secondary IDsNL56003.068.15 
- Public TitleThe effect of blood flow restriction with and without resistance exercise on muscle protein synthesis
- Scientific TitleThe effect of blood flow restriction with and without resistance exercise on muscle protein synthesis
- ACRONYMBFR study
- hypothesis
- Healt Condition(s) or Problem(s) studiedVascular shear rate, Muscle protein synthesis, Exercises
- Inclusion criteria-Males - Aged between 18-35 years - Healthy - 18.5≤BMI ≤30 kg/m2
- Exclusion criteria- Smoking - Resistance exercise >1 session/week - Sports/exercise >3 session/week - Lactose intolerant - A history of neuromuscular problems - Recent (<1 y) participation in amino acid tracer studies - Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription acne medications).
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingNone
- controlActive
- groupParallel
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 1-jul-2016
- planned closingdate31-mrt-2017
- Target number of participants20
- InterventionsBlood flow restriction of lower extremity with or without low load resistance exercise
- Primary outcomeMuscle protein synthesis (MPS) rate
- Secondary outcomeThe early (0-2h) and late (2-5h) muscle protein synthesis rates
- TimepointsThe early (0-2h), late (2-5h) and total (0-5h) muscle protein synthesis
- Trial web site
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIESPhD J. Nyakayiru
- CONTACT for SCIENTIFIC QUERIESPhD L. Verdijk
- Sponsor/Initiator NUTRIM School for Nutrition, Toxicology, and Metabolism Maastricht University
- Funding
(Source(s) of Monetary or Material Support)
STW/NWO
- Publications
- Brief summaryThe combined application of blood flow restriction and low load resistance exercise has been found to stimulate muscle protein synthetic rate to a similar extent as the traditional high load resistance exercise without blood flow restriction. However, it is still unclear whether blood flow restriction alone (without exercise) is a strong enough stimulus to significantly increase muscle protein synthesis.
The main aim of the current study will be to assess the effect of acute blood flow restriction and blood flow restriction combined with resistance exercise on the muscle protein synthetic rate in healthy young male subjects
- Main changes (audit trail)
- RECORD30-jun-2016 - 8-jul-2016


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