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Breath Taking!


- candidate number24661
- NTR NumberNTR5974
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR20-jul-2016
- Secondary IDs16/05 METC WUR
- Public TitleBreath Taking!
- Scientific TitleEffect of fat consumption of VOC profile in breath
- ACRONYM
- hypothesisCurrently, the effects of nutrition or specific food components, including those on absorption or metabolism, are mostly studied via parameters in blood samples. To reduce the burden for participants of nutritional intervention studies, there is a high need for non-invasive methods. Exhaled air contains large numbers of volatile organic compounds (VOCs) that may be derived from the body's internal metabolism. So this might be an interesting, non-invasive parameter.
- Healt Condition(s) or Problem(s) studiedRespiration, Volatile organic compounds (VOCs), Lipid metabolism
- Inclusion criteria- Caucasian male
- 18-35 years old
- Body mass index between 22-25 kg/m2
- Fat percentage between 8-15%
- Regular consumption of milk (products)
- Exclusion criteria- (symptoms of) cow's milk allergy
- lactose intolerance
- metabolic diseases
- (known symptoms of) (auto)immune diseases, like diabetes
- (known symptoms of) intestinal diseases, like: irritable bowel syndrome, intestinal malabsorption, diagnosed with celiac disease, Chron's disease, coliltis ulcerosa, short bowel syndrome or surgical bowel interventions leading to malabsorption
- usage of medication
- usage or hard drugs
- history of smoking
- claustrophobia
- unsuitable veins for blood sampling
- blood donation during the two months before the start of the study
- current participation in other scientific studies
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingNone
- controlNot applicable
- groupCrossover
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 30-mei-2016
- planned closingdate1-okt-2017
- Target number of participants12
- Interventionslow-fat milk (0.1% fat) vs high-fat milk (10% fat)
- Primary outcomepostprandial change in VOCs (volatile organic compounds) in exhaled air
- Secondary outcome-
- Timepointsvarious measurements for 5 hours postprandial
- Trial web site
- statusrecruitement status not public
- CONTACT FOR PUBLIC QUERIES Jeske Hageman
- CONTACT for SCIENTIFIC QUERIES Jeske Hageman
- Sponsor/Initiator Wageningen University (WUR)
- Funding
(Source(s) of Monetary or Material Support)
FrieslandCampina
- Publications
- Brief summaryExhaled air contains large numbers of volatile organic compounds (VOCs) that may be derived from the body's internal metabolism. The main ovjective of this study is to investigate whether it is possible to use VOCs in exhaled air as a parameter of lipid metabolism.
- Main changes (audit trail)26-jun-2017 -MT: secundaire uitkomsten verwijderd.
- RECORD20-jul-2016 - 26-jun-2017


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