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The effects of exercise on cognitive function and the formation of new neurons in the hippocampus in the brain.


- candidate number24726
- NTR NumberNTR6026
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR3-aug-2016
- Secondary IDsNL55943.018.15 
- Public TitleThe effects of exercise on cognitive function and the formation of new neurons in the hippocampus in the brain.
- Scientific TitleNEUROcognitive fitness: Studying changes in Hippocampal Adult neurogenesis and cognition induced by Physical Exercise
- ACRONYMNEUROSHAPE
- hypothesisPhysical exercise is not only beneficial for general health, but has also been shown to improve brain function (cognition) and influence brain structure (increase brain volume, especially in the hippocampus). However, the underlying neural mechanisms that cause this increase in volume are relatively unknown. Animal studies have shown that physical exercise can increase the formation and survival of new neurons, a process called neurogenesis. In addition, these new neurons are involved in cognition, especially in hippocampal-dependent pattern separation. We hypothesize that exercise could also increase neurogenesis in the human hippocampus. The recently developed and validated non-invasive magnetic resonance spectroscopy (MRS) now allows to reliably detect neurogenesis for the first time in the live human brain.
Exercise has also been demonstrated to influence the formation of new blood vessels (angiogenesis) in the hippocampus in rodents, a process which is closely linked to neurogenesis. Angiogenesis can be measured in the human brain by contrast-enhanced MRI, exploiting the leakiness of new vessels. In this study, we aim to study the effect of exercise on neurogenesis and angiogenesis and elucidate the link to brain function in the hippocampus.
- Healt Condition(s) or Problem(s) studiedNeurodegenerative disorders, Dementia, Depression
- Inclusion criteriaAge 18-30 years, BMI < 30 kg/m2, stable exercise history 3 months prior to study inclusion.
- Exclusion criteriacurrent intensive sports (>3 times/week), excessive smoking (>1 pack/day), alcohol (>21 units/week), or other regular drug use, history of chronic renal insufficiency, prior allergic reaction to Gadolinium-containing compounds, psychiatric disorders and general contraindications for MRI.
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingNone
- controlActive
- groupParallel
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 15-aug-2016
- planned closingdate15-feb-2017
- Target number of participants52
- InterventionsAerobic exercise intervention
Those subjects randomized to the aerobic exercise group will undergo a 12-week exercise program, in which they will engage in 45 minutes of aerobic exercise 3x weekly. Every two weeks the researchers will contact the subjects and will administer questionnaires.

Control exercise intervention
Those subjects randomized to the control group will undergo a 12-week exercise program, in which they will engage in 45 minutes of stretching and toning exercise 3x weekly. Every two weeks the researchers will contact the subjects and will administer questionnaires.
- Primary outcome- 1.28 ppm peak concentration in hippocampus, to assess neurogenesis (1H-MRS)
- new vascularization (rCBV in hippocampus using contrast-enhanced MRI)
- pattern separation
- Secondary outcome- hippocampal volume (T1-weighted MRI);
- VO2max (cardiopulmonary exercise test);
- neuropsychological functioning (cognitive and neuropsychological tests);
- lifestyle and dietary patterns (questionnaires);
- endothelial and neuronal growth factors (blood sampling)
- TimepointsAll measurements at baseline (week 0) and then again after 3 months of exercise (week 12-13).
- Trial web site
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIESMD, PhD Liesbeth Reneman
- CONTACT for SCIENTIFIC QUERIESMD, PhD Liesbeth Reneman
- Sponsor/Initiator Academic Medical Center (AMC), Amsterdam
- Funding
(Source(s) of Monetary or Material Support)
Amsterdam Brain and Cognition
- Publications
- Brief summary
- Main changes (audit trail)
- RECORD3-aug-2016 - 16-okt-2016


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