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Protein oxidation breath test: The influence of exercise on protein oxidation


- candidate number25452
- NTR NumberNTR6154
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR24-okt-2016
- Secondary IDsNL59615.042.16 
- Public TitleProtein oxidation breath test: The influence of exercise on protein oxidation
- Scientific TitleThe influence of different levels of exercise on protein oxidation measured by 13CO2 breath test
- ACRONYMEPOS
- hypothesisIngested protein derived amino acids are primarily used for synthesis of new protein, secondly all surplus is oxidized for energy. Exercise can influence protein metabolism and has shown in pilot experiments to reduce protein oxidation when exercise is given prior to the breath test.
- Healt Condition(s) or Problem(s) studiedProtein, Metabolism
- Inclusion criteriaMale
Age between 18 – 30 years
Be able to fast overnight
Be able to consume a 500 ml test drink within 5 minutes
Be able to fast for 5.5 hours
Body Mass Index between 20 and 25 kg/m2
Be able to speak the Dutch language and give written consent
Score ‘low risk’ on the ASCM Risk Classification form
- Exclusion criteriaDisease and/or being medically treated (e.g. diabetes mellitus)
Heart condition
Milk (protein) allergy or intolerance
Smoking
Drug use
Alcoholism, and no alcohol during the 4-day diets
Waist circumference ≥102 cm
- mec approval receivedno
- multicenter trialno
- randomisedyes
- masking/blindingNone
- controlNot applicable
- groupCrossover
- TypeSingle arm
- Studytypeintervention
- planned startdate 1-feb-2017
- planned closingdate1-jun-2017
- Target number of participants16
- InterventionsCycling: Submaximal Astrand test, 15 minutes of 30% at VO2max and 15 minutes of 60% at VO2max
- Primary outcomePercentage of given protein oxidized over 5,5 hours
- Secondary outcomeUrine urea and creatinin. Urea is a measure for protein intake
- Timepoints33 timepoints: a breath sample is given every 10 minutes, from 0 to 330 minutes
- Trial web site
- status[default]
- CONTACT FOR PUBLIC QUERIESMSc Gerlof Reckman
- CONTACT for SCIENTIFIC QUERIESMSc Gerlof Reckman
- Sponsor/Initiator University Medical Center Groningen (UMCG)
- Funding
(Source(s) of Monetary or Material Support)
- Publications
- Brief summary
- Main changes (audit trail)
- RECORD24-okt-2016 - 7-feb-2017


  • Indien u gegevens wilt toevoegen of veranderen, kunt u een mail sturen naar nederlands@trialregister.nl