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EEG reactivity study


- candidate number25664
- NTR NumberNTR6231
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR18-dec-2016
- Secondary IDsW15_287 # 15.0356 
- Public TitleEEG reactivity study
- Scientific TitleEEG reactivity for prognostication after cardiac arrest
- ACRONYMERS
- hypothesisAbsence of EEG reactivity predicts outcome after cardiac arrest
- Healt Condition(s) or Problem(s) studiedCardiac arrest, EEG, Resuscitation
- Inclusion criteria- patients after cardiac arrest
- age of 18 or older
- continuous EEG monitoring with at least 8 electrodes started within 24h post-resuscitation
- Targeted temperatur management treatment as per hospital protocol
- Exclusion criteria- Known history of another medical condition with life expectancy <6 months
- Any progressive brain illness, such as a brain tumor or neurodegenerative disease Pre-admission
- Modified Rankin Scale of 4 or lower
- Reason other than neurological condition to withdraw treatment
- Follow-up impossible due to logistic reasons
- Severe head injury
- mec approval receivedyes
- multicenter trialyes
- randomisedno
- group[default]
- TypeSingle arm
- Studytypeobservational
- planned startdate 27-apr-2015
- planned closingdate
- Target number of participants160
- InterventionsNone
- Primary outcomeBest neurological outcome (Cerebral performance category scale) at 3 months
- Secondary outcomeBest neurological outcome at hospital discharge;
Best neurological outcome at 6 months
- TimepointsICU discharge; 3 months post-resuscitation; 6 months post-resuscitation
- Trial web site
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIESMSc. M.M. Admiraal
- CONTACT for SCIENTIFIC QUERIESMD. PhD. Janneke Horn
- Sponsor/Initiator Academic Medical Center (AMC), Amsterdam
- Funding
(Source(s) of Monetary or Material Support)
Academic Medical Center (AMC)
- PublicationsAdmiraal M.M., van Rootselaar A.F. and Horn J., EEG reactivity in unconscious patients; A systematic review of methods and definitions, European Journal of Neurology 2016, DOI:10.1111/ene.13219
- Brief summaryPart of regular EEG examination is testing whether the EEG changes upon external stimulation, EEG reactivity. However, testing protocol and definition of EEG reactivity is often not clearly defined. Despite this, in cardiac arrest patients, reactivity is thought to be a reliable prognosticator. We aim to determine the prognostic value and added value besides other markers for prognosis of EEG reactivity testing in cardiac arrest patients.
- Main changes (audit trail)
- RECORD18-dec-2016 - 12-apr-2017


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