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van CCT (UK)

van CCT (UK)

Vegetables as a dietary source of nitrate

- candidate number26708
- NTR NumberNTR6276
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR15-feb-2017
- Secondary IDsNL58765.068.16 METC163028
- Public TitleVegetables as a dietary source of nitrate
- Scientific TitleDietary advice focused on increasing dietary nitrate in active individuals
- hypothesisWe hypothesize that dietary strategies focusing on increased intake of nitrate rich vegetables lead to a similar increase in plasma nitrate (and nitrite) concentration when compared to beetroot juice supplementation and, as such, may represent a feasible alternative for increasing dietary nitrate intake.
- Healt Condition(s) or Problem(s) studiedNitrate, Blood pressure, Vegetables
- Inclusion criteria- Healthy
- 18 - 45 years of age
- 18.5 < BMI < 30 kg/m2
- Engagement in regular physical activity (> 2 h/week)
- Exclusion criteria- Use of medication
- Smoking
- Currently supplementing diet with nitrate
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingNone
- controlActive
- groupCrossover
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 1-dec-2016
- planned closingdate1-jun-2017
- Target number of participants27
- InterventionsParticipants will receive 1-wk of dietary guidance in which they will be provided with a sufficient amount of vegetables, representing 400 mg (6.5 mmol) nitrate per serving (i.e. each day), including information about nitrate and nitrate rich recipes. In a randomized cross-over manner, participants will also follow a 1-wk supplementation protocol in which they will ingest 400 mg (6.5 mmol) nitrate per day in the form of concentrated red beetroot juice. Both trials will be separated by a 1-wk washout period.
- Primary outcomeThe primary parameter will be the increase in plasma nitrate concentrations from baseline fasting levels, which will be measured at 3h post-ingestion on day 1, 4, and 7 of the intervention.
- Secondary outcomePlasma nitrite concentrations, salivary nitrate and nitrite concentrations, blood pressure, urinary nitrosamines, and dietary intake will be determined throughout the trials as secondary parameters.
- Timepointsday 1, 4, and 7
- Trial web site
- statusstopped: trial finished
- CONTACT FOR PUBLIC QUERIESC. van der Avoort, MSc, PhD student Department of Human Movement Sciences Dr. L. Verdijk, PhD
- Sponsor/Initiator Maastricht University
- Funding
(Source(s) of Monetary or Material Support)
EAT2MOVE , Province of Gelderland, grant proposal PS2014-49
- Publications
- Brief summary
- Main changes (audit trail)
- RECORD15-feb-2017 - 19-mei-2017

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