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Repetitive behavior in gamblers and obsessive-compulsive patients: a brain imaging study


- candidate number25661
- NTR NumberNTR6318
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR15-dec-2016
- Secondary IDs60297 
- Public TitleRepetitive behavior in gamblers and obsessive-compulsive patients: a brain imaging study
- Scientific TitleCompulsivity in gambling disorder and obsessive-compulsive disorder: a functional magnetic resonance imaging (fMRI) study
- ACRONYMCompulsivity in gambling and OCD
- hypothesisReveal common mechanisms of compulsivity in OCD and GD and disorder specific characteristics of aspects that have been related to compulsivity: confidence in relation with preference for risky and ambiguous behavior, and (negative) outcome anticipation.
- Healt Condition(s) or Problem(s) studiedObsessive-compulsive disorder (OCD), Gambling addiction
- Inclusion criteriaOCD group:
DSM-5 diagnosis of OCD
No other psychiatric disorder
Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) score cut-off of 20
18-65 years of age
Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements

GD group:
DSM- 5 diagnosis for Gambling Disorder
No other psychiatric disorders.
Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements
18-65 years of age

HC group:
No current psychiatric diagnosis no history of OCD or GD.
Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements
18-65 years of age
- Exclusion criteriaAll groups:
Current major depressive disorder, bipolar disorder, psychotic disorder, alcohol or substance dependence, or any cognitive disorder as assessed with the MINI neurological disorders section
IQ below 80
insufficient command of the Dutch language
MRI contraindications such as metal implants, claustrophobia, pregnancy
recent (<2 weeks) use of psychotropic medication other than naltrexone (smoking and nicotine dependence is allowed in all groups).
Endocrinological disorders or regular use of corticosteroids
Current treatment with tricyclic antidepressant or antipsychotic medication
Use of other psychotropic medication (apart from SSRI's), or of recreational drugs over a period of 72 hours prior to each test session, and use of alcohol within the last 24 hours before each measurement
Irregular sleep/wake rhythm (e.g., regular nightshifts or cross timeline travel).
Pregnancy
- Left-handedness
OCD group and HC group: scoring lower than 5 on SOGS (gambling severity) questionnaire; hence not suffering from gambling problems.
GD and HC group: scoring lower than 5 Y-BOCS; hence not suffering from OCD symptoms.
- mec approval receivedno
- multicenter trialno
- randomisedno
- group[default]
- TypeSingle arm
- Studytypeobservational
- planned startdate 1-jan-2017
- planned closingdate1-jan-2018
- Target number of participants90
- InterventionsComputer tasks
- Primary outcome Confidence and brain activation as measured with fMRI during the confidence task
Risk taking and ambiguous behaviour measure with a cognitive task and its correlation with confidence task.
Compulsive checking behavior as determined by the checking task
- Secondary outcome Functional connectivity as measured with fMRI during the resting-state condition
Self-reports of development and experience of compulsions.
- TimepointsAt baseline (only one time point)
- Trial web sitenot applicable
- statusplanned
- CONTACT FOR PUBLIC QUERIES Ruth Holst, van
- CONTACT for SCIENTIFIC QUERIESProf. dr. D. Denys
- Sponsor/Initiator Academic Medical Center (AMC), Amsterdam
- Funding
(Source(s) of Monetary or Material Support)
ABC- talent grants
- Publications
- Brief summaryInvestigating and comparing two disorders (i.e., obsessive compulsive disorder and disordered gambling) that both have compulsive behaviors central to their pathology can elucidate common mechanisms of compulsivity in psychiatry. In the present study we will investigate behavioral and neural mechanisms contributing to these behaviors. We will explore three different aspects that have been related to compulsivity in previous studies: risky and ambiguous behavior, confidence and (negative) outcome anticipation. Besides investigating the common mechanisms of compulsivity in OCD and GD, we aim to elucidate disorder specific characteristics. To this end we will use fMRI imaging and neurocognitive tasks to investigate the neurobiological correlates of these compulsive behaviors in both gambling disorder and obsessivecompulsive disorder.
- Main changes (audit trail)
- RECORD15-dec-2016 - 25-mei-2017


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