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Het effect van de inname van een vleesvervanger op spieropbouw in jongere mannen


- candidate number27138
- NTR NumberNTR6380
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR25-apr-2017
- Secondary IDsMETC 163055 
- Public TitleHet effect van de inname van een vleesvervanger op spieropbouw in jongere mannen
- Scientific TitleThe anabolic response following ingestion of a plant-based protein product in vivo in healthy young men
- ACRONYMVeggiebolic
- hypothesisH0= Postprandial muscle protein synthesis rates do not differ between the 2 intervention groups (P>0.05)
H1= Postprandial muscle protein synthesis rates differ between the 2 intervention groups (P<0.05)
- Healt Condition(s) or Problem(s) studiedMuscle protein synthesis, Muscles
- Inclusion criteria Males
Aged between 18 - 35 years
Healthy, recreationally active (max 3 days per week performing activities)
BMI 18.5 27.5 kg/m2
- Exclusion criteria Females
Diagnosed diabetes
Wheat allergy
Celiac disease
Smoking
Diagnosed metabolic or intestinal disorders
A history of neuromuscular problems
Any medications known to (or may) affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).
Participation in structured resistance exercise program
Previous participation in a 13C amino acid tracer study within the last year
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingNone
- controlActive
- groupParallel
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 1-mei-2017
- planned closingdate31-dec-2018
- Target number of participants24
- InterventionsSubjects will either consume 40 g plantbased or animal protein (isonitrogenous amount) in the form of a ready-to-eat product (n = 12 per group).
- Primary outcomePrimary study parameters include myofibrillar protein synthesis rates, expressed as FSR (%/h), using muscle-protein bound L-[ring-13C6]-phenylalanine enrichments and muscle tissue-free and plasma L-[ring-13C6]-phenylalanine enrichments as precursor.
- Secondary outcomeSecondary endpoints will be plasma amino acid concentrations (total amino acid profile), glucose, and insulin concentrations.
- TimepointsBlood and muscle samples will be collected at regular time intervals (bloodsamples every hour, 3 muscle biopsies during the 5h postprandial period).
- Trial web site
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIESDr. L.J.C. Loon, van
- CONTACT for SCIENTIFIC QUERIESDr. L.J.C. Loon, van
- Sponsor/Initiator Maastricht University Medical Center (MUMC+)
- Funding
(Source(s) of Monetary or Material Support)
TIFN
- Publications
- Brief summary
- Main changes (audit trail)
- RECORD25-apr-2017 - 21-jun-2017


  • Indien u gegevens wilt toevoegen of veranderen, kunt u een mail sturen naar nederlands@trialregister.nl