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A virtual reality game for patients with Obsessive-Compulsive Disorder : Neuro-imaging


- candidate number27087
- NTR NumberNTR6420
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR12-apr-2017
- Secondary IDs2016_297 METC AMC
- Public TitleA virtual reality game for patients with Obsessive-Compulsive Disorder : Neuro-imaging
- Scientific TitleA virtual reality game for patients with Obsessive-Compulsive Disorder : Neuro-imaging
- ACRONYMVR for OCD
- hypothesisThe primary objective of this study is to investigate if a specifically designed VR-game is able to activate the pathophysiological substrate associated with OCD in OCD patients, as opposed to healthy controls. This will be investigated by visualizing brain activity using fMRI while participants play the game. We hypothesize increased VR-game output scores and increased brain activity within the orbitofrontal cortex, anterior cingulate cortex and the amygdala in OCD patients and relative to healthy controls.
The secondary objective is to investigate the correlation between the degree of activation of the pathophysiological substrate and the severity of OCD in OCD patients.
- Healt Condition(s) or Problem(s) studiedObsessive-compulsive disorder (OCD)
- Inclusion criteria- Diagnosis of primary OCD by DSM-IV criteria,
- Age between 18-65
- Written informed consent of the subject
- Exclusion criteria- Severe neurological disorders (including seizures) and cardiovascular disorders
- Use of psychiatric medication including tricyclic antidepressants, antipsychotics and benzodiazepines.
- Mental retardation
- Use of medication potentially influencing cerebral blood flow and the cardiovascular system
- Severe comorbid axis I disorders including schizophrenia like disorders and bipolar disorder
- Alcohol or substance abuse (including benzodiazepines) during the last 6 months
- Use of alcohol or benzodiazepines in the 24 hours prior to investigation or recreational drugs in the 72 hours prior to investigation
- Abnormal hearing and uncorrected vision Irregular sleep/wake rhythm (e.g. regular nightshifts or cross timeline travel)
- Contraindications for fMRI
- mec approval receivedyes
- multicenter trialno
- randomisedno
- groupCrossover
- Type2 or more arms, non-randomized
- Studytypeintervention
- planned startdate 1-mei-2017
- planned closingdate
- Target number of participants54
- InterventionsIn this research project we will investigate a virtual reality game (VR-game) for OCD. This VR-game is interactive and designed to provoke and assess OCD symptoms in a controlled and standardized way. In the VR-game OCD patients encounter 15 OCD-specific items like running gas, an open window and a dirty toilet. They are asked to rate their emotional responses, subdivided in anxiety, tension, uncertainty and urge to control on a 0-10 visual analogue scale. Subsequently they are expected to intervene in the OCD-specific item and rate their emotional responses again afterwards. Thereafter, OCD patients have the option to perform compulsive behavior (e.g. checking or repeating the intervention) followed by another rating of their emotional responses (for an overview, see figure 1).
- Primary outcomeMain study parameters involve (1) the VR-game output scores and (2) brain activity on fMRI and (3) Y-BOCS scores
- Secondary outcomeNot applicable
- TimepointsSubjects will participate only once, participation will take 3 hours.
- Trial web siteNot applicable
- status[default]
- CONTACT FOR PUBLIC QUERIES Martine van Bennekom
- CONTACT for SCIENTIFIC QUERIES Martine van Bennekom
- Sponsor/Initiator Academic Medical Center (AMC), Amsterdam
- Funding
(Source(s) of Monetary or Material Support)
Academic Medical Center (AMC)
- Publications
- Brief summaryObsessive-compulsive disorder (OCD) is a chronic psychiatric disorder characterized by obsessions and repetitive compulsions. To date, a diagnosis of OCD is based on retrospective and subjective measures. There is a need for standardized and objective tools to improve diagnostics.
Interestingly, virtual reality (VR) can be used to actively provoke and assess OCD specific symptoms in a controlled and standardized environment. In a former study, we showed the VR-game is capable of inducing OCD symptoms of self-reported anxiety and compulsive behaviour in OCD patients. We will now investigate whether the VR-game is able to activate the pathophysiological substrates of OCD. This will support the objectivity and specificity of the use of the VR-game as a tool to provoke and assess OCD symptoms.
The primary objective of this study is to investigate if the VR-game is able to activate the pathophysiological substrate associated with OCD in OCD patients, as opposed to healthy controls The secondary objective is to investigate the correlation between the activity of the substrate and the severity of OCD.
We will perform a cross-sectional study including 27 OCD patients and 27 healthy controls. The participants will play the VR-game while time alterations in blood flow are visualized with fMRI. A comparison between OCD-patients and healthy controls will be made.
- Main changes (audit trail)
- RECORD12-apr-2017 - 25-jun-2017


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