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proton pump inhibitors and low magnesium in older patients.


- candidate number27195
- NTR NumberNTR6431
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR11-mei-2017
- Secondary IDs2017.05.02.01 JBZ study number
- Public Titleproton pump inhibitors and low magnesium in older patients.
- Scientific TitleProton pump inhibitors and hypomagnesaemia in geriatric inpatients; identifying risk factors
- ACRONYM
- hypothesisPPIs are prescribed very frequently and might cause potentially severe hypomagnesaemia. We carried out a study focussing on the prevalence of hypomagnesaemia in geriatric inpatients using PPI and evaluated risk factors contributing to this effect. Mortality and length of hospital admission were also explored
- Healt Condition(s) or Problem(s) studiedPPI, Hypomagnesaemia
- Inclusion criteria- Admission in the geriatric ward in Jeroen Bosch Hospital between August 1st, 2014 and April 30th, 2017. This start date was chosen because since then magnesium was included in the regular laboratory examination.
- Magnesium serum levels determined in venous blood must be known.
- Medication prescribed before and during admission must be known.
- Exclusion criteria- Age below 65 years.
- Patients with re-admissions, since all patients are included once in this research.
- mec approval receivedno
- multicenter trialno
- randomisedno
- group[default]
- Type[default]
- Studytypeobservational
- planned startdate 15-mei-2016
- planned closingdate
- Target number of participants1500
- Interventionsnot applicable
- Primary outcomeThe prevalence of hypomagnesaemia in hospitalised patients using a PPI in a geriatric ward
- Secondary outcomeThe secondary outcome will be risk factors which will be presented as odd ratios with corresponding 95% confidence interval
- Timepointsnot applicable
- Trial web site
- status[default]
- CONTACT FOR PUBLIC QUERIESMD PhD Carolina Keijsers
- CONTACT for SCIENTIFIC QUERIESMD PhD Carolina Keijsers
- Sponsor/Initiator Jeroen Bosch Hospital
- Funding
(Source(s) of Monetary or Material Support)
Jeroen Bosch Hospital
- Publications
- Brief summaryPPIs are prescribed very frequently and might cause potentially severe hypomagnesaemia. We will carry out a study focussing on the prevalence of hypomagnesaemia in geriatric inpatients using PPI and evaluated risk factors contributing to this effect. Mortality and length of hospital admission were also explored.
METHODS: This observational, retrospective cohort study was designed to examine the association between PPI and hypomagnesaemia in geriatric inpatients, identify independent predictors for proton-pump-inhibitor-induced hypomagnesaemia (PPIIH) and explore its effects on mortality and length of hospital admission.
- Main changes (audit trail)
- RECORD11-mei-2017 - 28-jun-2017


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