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Evaluation of Vascular care in Alzheimer's disease.


- candidate number2046
- NTR NumberNTR646
- ISRCTNISRCTN74902933
- Date ISRCTN created28-apr-2006
- date ISRCTN requested25-apr-2006
- Date Registered NTR30-mrt-2006
- Secondary IDsN/A 
- Public TitleEvaluation of Vascular care in Alzheimer's disease.
- Scientific TitleEvaluation of Vascular care in Alzheimer's disease.
- ACRONYMEVA
- hypothesisIntensive vascular care, aimed at secundary prevention of cerebrovascular disease, is efficacious in patients with Alzheimer's disease that have vascular lesions on MRI.
- Healt Condition(s) or Problem(s) studiedAlzheimer's disease
- Inclusion criteriaPatients with early Alzheimer's disease according to clinical criteria, that have on MRI either cerebral infarcts or significant white matter abnormalities.
- Exclusion criteria1. Severe dementia;
2. Limited life expectancy.
- mec approval receivedyes
- multicenter trialyes
- randomisedyes
- masking/blindingNone
- controlActive
- groupParallel
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 1-jun-2002
- planned closingdate1-mei-2007
- Target number of participants130
- InterventionsMulticomponent intervention consisting of a combination of measures aimed at prevention of cerebrovascular disease (platelet aggregation inhibitors, statin, strict regulation of blood pressure, diabetes, life style interventions concerning smoking, body weight, excercise). Patients in the control group will recieve 'regular care' i.e. less frequent visits, without specific attention to vascular risk factors.
- Primary outcomeChange in impairments after two years of follow up in activities of daily living as measured by the Interview for Deterioration in Daily life in dementia (IDDD).
- Secondary outcomeChange in cognitive functioning, behavioral abnormalities, blood pessure, body weight. New lesions on MRI after two years.
- TimepointsN/A
- Trial web siteN/A
- statusinclusion stopped: follow-up
- CONTACT FOR PUBLIC QUERIESProf. Dr. W.A. Gool, van
- CONTACT for SCIENTIFIC QUERIESProf. Dr. W.A. Gool, van
- Sponsor/Initiator Academic Medical Center (AMC, Amsterdam)
- Funding
(Source(s) of Monetary or Material Support)
ZON-MW, The Netherlands Organization for Health Research and Development
- PublicationsN/A
- Brief summaryFrequently patients with a clinical diagnosis of Alzheimer's disease also harbour cerebrovascular lesions on neuroimaging. It is not clear to what extent these lesions contribute to (1) functional impairments, and (2) the prognosis of these patients. In this open multicentre clinical trial the hypothesis is tested that intensive vascular care is efficacious in these patients, resulting in slower deterioration after a follow up of two yeras in patients receiving such care, in comparison to patients receiving standard care.
- Main changes (audit trail)
- RECORD30-mrt-2006 - 27-nov-2009


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