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van CCT (UK)

van CCT (UK)

The effect of training status on muscle energy metabolism in young males

- candidate number27325
- NTR NumberNTR6470
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR26-mei-2017
- Secondary IDsNL60823.081.17  
- Public TitleThe effect of training status on muscle energy metabolism in young males
- Scientific TitleMitochondrial Capacity in Untrained and Endurance-trained Young Males
- hypothesisMitochondrial capacity measured using different, non-invasive techniques can be used to analyse mitochondrial capacity in future studies
- Healt Condition(s) or Problem(s) studiedAging, Sarcopenia, Mitochondrail function
- Inclusion criteria 18-28 year old male
BMI 18.5-25 kg/m2
VO2max ≤ 47 mL/kg/min or VO2max ≥ 57 mL/kg/min
Performed a valid VO2max test (In order for the test to be considered valid two out of three of the following conditions should be met: 1) The maximal heart rate is within 10 beats of the predicted maximum (220 age) 2) A plateau in in VO2 was reached; VO2 fails to increase with 150 mL/min, despite an increase in work load 3) Respiratory exchange ratio (RER) ≥ 1.00 has been achieved) and is has a
- Exclusion criteria Health concerns regarding respiratory and pulmonary diseases, such as COPD, (exercise induced) asthma and cardiovascular disease.
(known symptoms of) Metabolic diseases, such as type I or II diabetes,
Regular smoker (defined as smoking >5 cigarettes per week)
Haemoglobin concentrations below 8.0 mmol/L
Recent usage (within four months) of supplements with suggestive training effects, such as creatine phosphate, EPO or anabolic steroids.
Usage of recreational drugs, such as marihuana, amphetamines and cocaine during the study (starting after first screening day)
Suffers from (sport) injury that hampers maximal exercise performance
Blood donation during the course of study
Current participation in other clinical trials
Employed or undertaking a thesis or internship at the department of Human and Animal Physiology
- mec approval receivedyes
- multicenter trialno
- randomisedno
- group[default]
- Type2 or more arms, non-randomized
- Studytypeobservational
- planned startdate 1-sep-2017
- planned closingdate1-okt-2017
- Target number of participants16
- InterventionsCross-sectional study design in which subject will be selected on training status.
- Primary outcomeThe primary objective of this study is to measure mitochondrial capacity using NIRS in order to verify if NIRS can be used to analyse differences in training status in a normal student population.
- Secondary outcome To measure mitochondrial capacity in gastrocnemius and the wrist flexor muscles to compare which measurement site correlates best to measurements of whole body oxygen consumption.

To study the correlation between muscle-recovery to pre-exercise state, expressed as Tc measured using NIRS, and whole body-recovery to pre-exercise state, expressed as EPOC measured using indirect calorimetry.

To critically asses the use of the PBMCs as a functional biomarker and assess correlations with whole body and skeletal muscle mitochondrial capacity.

To investigate to which extend physical activity questionnaires can be used to reliably estimate VO2max in young and healthy and generally comparatively fit) males
- TimepointsCross-sectional study design
- Trial web site-
- statusplanned
- Sponsor/Initiator Prof. dr. Jaap Keijer
- Funding
(Source(s) of Monetary or Material Support)
- Publications
- Brief summary
- Main changes (audit trail)
- RECORD26-mei-2017 - 3-jul-2017

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