Who are we?


Signup for

Online registration

Log in to register
your trial

Search a trial




van CCT (UK)

van CCT (UK)

Oxytocin, friendship, and dealing with emotions

- candidate number27377
- NTR NumberNTR6513
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR12-jun-2017
- Secondary IDsNL60593.028.17 METC brabant
- Public TitleOxytocin, friendship, and dealing with emotions
- Scientific TitleEffects of oxytocin and social support on stress reactivity
- hypothesisThe aim of the study is to examine whether intranasal oxytocin enhances beneficial effects of social support during stress
- Healt Condition(s) or Problem(s) studiedStress reactivity
- Inclusion criteriaFemale, age 18-30 years, without children
- Exclusion criteriaUse of medication (except contraceptives), drug or alcohol abuse, psychiatric disorder, neurological or cardiovascular disease, high blood pressure, nasal disease or obstruction, pregnancy, and breast feeding.
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingDouble
- controlPlacebo
- groupParallel
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 1-sep-2017
- planned closingdate1-sep-2019
- Target number of participants180
- InterventionsA nasal oxytocin spray containing 24 IU oxytocin (6 puffs) is administered once. This will be compared with a placebo nasal spray (between-subjects design).
- Primary outcome1) stress reactivity (self-report, cortisol, physiological reactivity) during social stress
2) stress reactivity (self-report, cortisol, physiological reactivity) during physical stress
3) Interpersonal distance between participant and virtual persons with varying emotional facial expressions in a Virtual Reality Paradigm.
- Secondary outcomeThe moderating roles of attachment style, parenting style and autonomy-connectedness on the effects of oxytocin and social support on stress will be examined.
- Timepoints1 labession. Self reported stress (STAI short form) and salivary cortisol will be measured at 5 time points. Physiological reactivity (heart rate) will be measured during mental (virtual version of the Trier Social Stress Test) and physical stress (Cold Pressor Test).
- Trial web sitena
- statusplanned
- CONTACT for SCIENTIFIC QUERIESDr. Madelon Hendricx-Riem
- Sponsor/Initiator Tilburg University
- Funding
(Source(s) of Monetary or Material Support)
Center of Research on Psychological and Somatic disorders, Tilburg University, Alumni Fonds, Tilburg University
- Publications
- Brief summarySusceptibility for stress-related psychopathology, e.g. anxiety disorders, may arise in part when individuals are not able to form stable, long-lasting bonds, and to profit from the stress-buffering effects of social support. Oxytocin has been shown to play an important role in attachment to others and prosocial behaviour. However, it is yet unclear whether, how, and for whom oxytocin may be used in a clinical setting, most notably because many individual differences exist in the stress-buffering effects of oxytocin. We hypothesize that oxytocin may increase the stress-buffering effects of social support, but that this effect depends on individual variations in attachment, parenting styles and autonomy-connectedness. These effects may also be more pronounced in socially stressful situations, compared with a general stressor. Further, in line with the hypothesis that interpersonal functioning is essential for psychological well-being, this study tests whether oxytocin and social support affect the interpersonal closeness one is comfortable with, and whether this varies for different emotions of the other person. Individual differences in attachment, parenting experiences during childhood and autonomy-connectedness are hypothesized to influence preferred interpersonal closeness and stress during this task.
- Main changes (audit trail)
- RECORD12-jun-2017 - 11-jul-2017

  • Indien u gegevens wilt toevoegen of veranderen, kunt u een mail sturen naar