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Project Y: searching for the cause of differences in disease course in MS


- candidate number27454
- NTR NumberNTR6546
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR23-jun-2017
- Secondary IDs2017.247 METc VUMC  
- Public TitleProject Y: searching for the cause of differences in disease course in MS
- Scientific TitleProject Y: searching for the cause of phenotype diversity in MS
- ACRONYMProject Y
- hypothesisOur objective is to identify determinants that explain phenotypic variability in MS while excluding age as a confounding factor and to detect determinants which may guide intervention strategies and predict the disease course in MS.
- Healt Condition(s) or Problem(s) studiedMultiple sclerosis (MS)
- Inclusion criteriaPatients
- Born in 1966 in the Netherlands
- Currently living in the Netherlands
- Diagnosis of MS (according to McDonald criteria, revised by Polman 2010)

Controls
- Born in between 1965 and 1967 in the Netherlands
- Currently living in the Netherlands
- No history of MS
- Exclusion criteriaPatients
- None

Controls
- Comorbidity that interferes with participation in this study
- mec approval receivedyes
- multicenter trialno
- randomisedno
- group[default]
- Type[default]
- Studytypeobservational
- planned startdate 1-sep-2017
- planned closingdate1-sep-2020
- Target number of participants375
- InterventionsNone
- Primary outcomeClinical outcome (disease course), consisting of age of onset, disease duration, affected parts of the CNS, previous and current MS subtype, recovery from relapses, disability scores and speed of developing disability
- Secondary outcome- Objective cognitive functioning
- Imaging parameters
- Sample parameters (biomarkers)
- Comorbidities
- Quality of life
- Exposure to various determinants (e.g. smoking, alcohol, sunlight, diet)
- TimepointsOne-time data collection
- Trial web site
- statusplanned
- CONTACT FOR PUBLIC QUERIES D. Doesburg
- CONTACT for SCIENTIFIC QUERIES D. Doesburg
- Sponsor/Initiator VU University Medical Center
- Funding
(Source(s) of Monetary or Material Support)
VU University Medical Center
- Publications
- Brief summaryThe main objective of this study is to identify determinants that explain phenotypic variability in multiple sclerosis (MS) while excluding age as a confounding factor. Therefore we aim to include all people with MS born in The Netherlands in 1966, which will result in an unbiased population based cohort. This cohort will be subjected to extensive examinations of a wide array of outcome measures and potential determinants. Detection of these determinants may guide intervention strategies and predict disease course in MS.
- Main changes (audit trail)
- RECORD23-jun-2017 - 30-jul-2017


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