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Plant proteins for muscle growth


- candidate number27464
- NTR NumberNTR6548
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR27-jun-2017
- Secondary IDsNL60500.068.17 METC173001
- Public TitlePlant proteins for muscle growth
- Scientific TitleAnabolic properties of plant based proteins
- ACRONYMAPPROS
- hypothesisIt is hypothesized that the ingestion of plant based proteins will result in a similar muscle protein synthetic response compared to animal based proteins.
- Healt Condition(s) or Problem(s) studiedProtein, Inflammation of peri-implant tissues, Muscle growth, Muscle metabolism
- Inclusion criteria- Male
- Aged 18-35 y inclusive
- BMI 18.5 27.5 inclusive
- Healthy recreationally active
- Exclusion criteria- Females
- Wheat allergy
- Celiac disease
- Allergies to milk proteins
- Lactose intolerance
- Smoking
- Diagnosed diabetes
- Diagnosed metabolic or intestinal disorders
- A history of neuromuscular problems
- Any medications known to (or may) affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).
- Participation in structured resistance exercise program
- Previous participation in a 13C amino acid tracer study within the last 1 year
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingDouble
- controlActive
- groupParallel
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 23-mei-2017
- planned closingdate31-dec-2018
- Target number of participants84
- InterventionsSubjects will consume 30 g of protein in the form of a beverage.
- Primary outcomePrimary study parameter is myofibrillar protein synthesis rate.
- Secondary outcomeSecondary endpoints will be plasma amino acid concentrations, glucose, and insulin concentrations.
- TimepointsBlood and muscle samples will be collected at regular time intervals.
- Trial web site
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIES Philippe Pinckaers
- CONTACT for SCIENTIFIC QUERIES Philippe Pinckaers
- Sponsor/Initiator Maastricht University Medical Center (MUMC+)
- Funding
(Source(s) of Monetary or Material Support)
Top Institute Food & Nutrition
- Publications
- Brief summarySkeletal muscle mass maintenance is regulated by two main anabolic stimuli, food intake and physical activity. Dietary protein intake directly stimulates muscle protein synthesis rates and inhibits muscle protein breakdown. Therefore, the post-prandial muscle protein synthetic response to feeding plays a key regulatory role in skeletal muscle mass maintenance.

The capacity of dietary protein to stimulate post-prandial muscle protein accretion varies between protein sources. More than half of the total amount of dietary protein that is consumed by humans worldwide is of plant origin, with plant based proteins providing up to 80% of dietary protein consumed in less developed regions. Overall it is assumed that plant based proteins are less potent in stimulating post-prandial muscle protein synthesis. However, the anabolic properties of plant based protein sources have hardly been assessed. Therefore, this project will investigate the anabolic properties of plant based proteins.
- Main changes (audit trail)
- RECORD27-jun-2017 - 30-jul-2017


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