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van CCT (UK)

van CCT (UK)

Het effect van koude op post-prandiaal triglyceride metabolisme

- candidate number27561
- NTR NumberNTR6573
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR17-jul-2017
- Secondary IDsMETC 173020 NL61819.068.17
- Public TitleHet effect van koude op post-prandiaal triglyceride metabolisme
- Scientific TitleThe effect of cold exposure on post-prandial metabolism of triglycerides
- hypothesis1. During cold exposure, we aim to stimulate (lipid) metabolism of BAT and muscle tissue. During this cooling process we will perform a two meal test to study the effect of cold exposure on triglyceride metabolism.
2. We expect that after cold exposure, BAT will take up plasma fatty acids to replenish its intracellular lipid storage. We therefore will perform a meal test after three hours of cold exposure to study this effect on triglyceride metabolism.
3. The two aforementioned meal tests will be compared with the two meal test during thermoneutral condition.
- Healt Condition(s) or Problem(s) studiedHyperlipidemia, Hypertriglyceridaemia
- Inclusion criteria- Signed informed consent
- Caucasian
- Aged 20-50 years at the start of the study
- Body mass index (BMI) 20-30 kg/m2
- Stable dietary habits (no weight loss or gain of more than 5 kg in the past 3 months
- Stable sedentary lifestyle (not more than 2 hours of sports per week)
- Female participants: Using Microgynon 30 or levonorgestrel/ethinylestradiol
- Exclusion criteria- Use of cholesterol or lipid-lowering medication
- Active pregnancy during the study period
- Active diseases (cardiovascular, diabetes mellitus, liver, kidney, cancer or other)
- Participation in earlier research that included PET/CT scanning for detection of brown adipose tissue activity in the last 3 months
- Alcohol consumption of >2 servings per day
- Smoking in the past 6 months
- Haemoglobin content <8.4 mmol/L
- mec approval receivedno
- multicenter trialno
- randomisedyes
- masking/blindingNone
- controlNot applicable
- groupCrossover
- TypeSingle arm
- Studytypeintervention
- planned startdate 1-okt-2017
- planned closingdate1-okt-2018
- Target number of participants17
- InterventionsCold exposure via a water-perfused cooling suit.

High fat milkshakes
- Primary outcomePostprandial triglyceride metabolism: post prandial TG levels
Postprandial lipoprotein metabolism: post prandial values of other lipoproteins besides TG
Presence and activity (glucose uptake) of brown adipose tissue measured by a 18F-FDG PET/CT scan
Muscle mitochondrial respiration
Metabolic parameters of sympathic activity: plasma catecholamines
- Secondary outcomeCore body temperature
Skin body temperatures
- Timepoints-
- Trial web site-
- statusplanned
- Sponsor/Initiator Maastricht University
- Funding
(Source(s) of Monetary or Material Support)
Cardiovasculair Onderzoek Nederland (CVON)
- Publications-
- Brief summaryBrown adipose tissue (BAT), is a special fat tissue known for its capacity to produce heat through mitochondrial uncoupling. To produce heat, BAT consumes its intracellular triglyceride content. In order to replenish this intracellular content, we hypothesize that BAT will take up plasma fatty acids and triglycerides.
While doing this, BAT activation may provide a way to lower plasma lipid levels and decrease this cardiovascular risk factor.

In this study we will use high fat milkshakes to induce post-prandial hypertriglyceridaemia. During three different test days we will expose the subjects to cold exposure, to study the effect of cold exposure on post-prandial triglyceride metabolism.

A 18-FGD PET CT scan will be used to asses BAT activity in these subjects. The effect of cold on post-prandial triglyceride values will be correlated with BAT activity.

Also muscle biopsies will be taken to study the role of the skeletal muscle in post-prandial triglyceride metabolism
- Main changes (audit trail)
- RECORD17-jul-2017 - 5-aug-2017

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