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The associations of maternal folic acid intake and folate, vitamin B12 and homocysteine concentrations with dental development in children


- candidate number27417
- NTR NumberNTR6594
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR16-jun-2017
- Secondary IDsMEC-2012-165 
- Public TitleThe associations of maternal folic acid intake and folate, vitamin B12 and homocysteine concentrations with dental development in children
- Scientific Titlematernal vitamins B and child dental development
- ACRONYM
- hypothesisWe investigated the associations of maternal folic acid use and folate, vitamin B12 and homocysteine concentrations in early pregnancy with dental development in children. Secondly, we checked whether these associations were modified by MTHFR-C677T polymorphism.
- Healt Condition(s) or Problem(s) studiedFolic acid, Development, Vitamin B12
- Inclusion criteriaMothers with available information on folic acid use and folate , vitamin B12 or homocysteine concentrations; Singleton life born children; Children participating in 9 years follow up measurements
- Exclusion criteriatwin births, children who did not attend follow up visits at the age of 9 years, excluded children without OPG available or bad image
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingSingle
- controlNot applicable
- groupCrossover
- TypeSingle arm
- Studytypeobservational
- planned startdate 1-mrt-2017
- planned closingdate18-jun-2017
- Target number of participants3728
- Interventionsobservational study, no intervention applicable
- Primary outcomedental development in children
- Secondary outcomedental development in children
- Timepointsone time point, cross sectional
- Trial web site
- statusstopped: trial finished
- CONTACT FOR PUBLIC QUERIES Edwin M Ongkosuwito
- CONTACT for SCIENTIFIC QUERIES Edwin M Ongkosuwito
- Sponsor/Initiator Erasmus Medical Center, School of Law and Faculty of Social Sciences of the Erasmus University Rotterdam, the Municipal Health Service Rotterdam area, the Rotterdam Homecare Foundation, Stichting ArtsenLaboratorium en Trombosedienst (SALT)
- Funding
(Source(s) of Monetary or Material Support)
- Publications
- Brief summaryMaternal nutritional status, including vitamins can impact the offspring’s tooth formation and mineralization.
We investigated the associations of maternal folic acid use and folate, vitamin B12 and homocysteine concentrations in early pregnancy with dental development in children. Secondly, we checked whether these associations were modified by MTHFR-C677T polymorphism.
This investigation was embedded in the Generation R study, a multi-ethnic population-based prospective. Information on folic acid supplement use was obtained by questionnaires at the enrolment of the study.
Maternal folic acid, vitamin B12 and homocysteine concentrations were measured from the venous samples drawn in early pregnancy. Dental development in 10 year old children was defined using the Demirjian method and the Dutch standard to calculate dental age.
Multivariate regression models were built to analyze the studied associations. Children of mothers who used folic acid supplement either when the pregnancy was known (β, -0.09; 95% CI: -0.17, -0.01) or in a periconceptional time (β, -0.12; 95% CI: -0.20, -0.04) had lower dental age, reflected in the delayed development of the mandibular first premolar and canine. In contrast, higher vitamin B12 concentration in the first trimester of pregnancy was associated with advanced maturity of second premolar (β, 0.20; 95% CI: 0.00, 0.40), first premolar (β, 0.23; 95% CI: 0.01, 0.44) and canine (β, 0.39; 95% CI: 0.17, 0.62). Homocysteine and folate concentrations were not significantly associated with dental age or development of any mandibular tooth. MTHFR-C677T polymorphism did not modify the studied associations. In conclusion, folic acid use during pregnancy is associated with a delayed dental development in children, while maternal vitamin B12 in early pregnancy is associated with advanced dental development.
- Main changes (audit trail)
- RECORD16-jun-2017 - 25-aug-2017


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