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TransplantLines Historical Adult Liver Cohort (TxL-HALC)


- candidate number27799
- NTR NumberNTR6650
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR29-aug-2017
- Secondary IDsUMCG METc 2014/77 
- Public TitleTransplantLines Historical Adult Liver Cohort (TxL-HALC)
- Scientific TitleTransplantLines Historical Adult Liver Cohort (TxL-HALC)
- ACRONYMTxL-HALC
- hypothesisThe overall 1- and 5-year survival rates after liver transplantation are nowadays well established at approximately 90% and 70%, respectively. Unfortunately, long-term patient survival rates after OLT lag behind, with an overall 20-year survival rate of approximately 50%. Where most research has focused on immunosuppression, comorbidities and infections, we hypothesize that other, yet unknown, patient-related factors may influence long-term survival. One of these factors, among others, could be urinary creatinine excretion rate as an established marker of total body muscle mass. This study is a biobank and observational cohort study to investigate this hypothesis.
- Healt Condition(s) or Problem(s) studiedLiver transplantation, Survival
- Inclusion criteriaAge >18years, prognosis > 1 year, stable outpatients situation
- Exclusion criteriaSurvival less than one year after liver transplantation, patients lost to follow-up
- mec approval receivedyes
- multicenter trialno
- randomisedno
- group[default]
- Type[default]
- Studytypeobservational
- planned startdate 1-jan-1993
- planned closingdate31-dec-2030
- Target number of participants1000
- InterventionsNo interventions, the cohort is observational
- Primary outcomeall-cause mortality
- Secondary outcomedeath-censored graft failure
- TimepointsBaseline measurements, routine outpatient clinical visits
- Trial web siteNot applicable
- statusinclusion stopped: follow-up
- CONTACT FOR PUBLIC QUERIESDr. V.E. de Meijer
- CONTACT for SCIENTIFIC QUERIESDr. V.E. de Meijer
- Sponsor/Initiator University Medical Center Groningen (UMCG)
- Funding
(Source(s) of Monetary or Material Support)
University Medical Center Groningen (UMCG)
- Publications
- Brief summaryThe last decades short-term survival in liver transplant recipients has been markedly improved, however long-term survival is still being restricted. Where most research has focused on immunosuppression, comorbidities and infections, we hypothesize that other, yet unknown, patient-related factors may influence long-term survival. One of these factors, among others, could be urinary creatinine excretion rate as an established marker of total body muscle mass. This study is a biobank and single-center observational cohort study to investigate this hypothesis.
- Main changes (audit trail)
- RECORD29-aug-2017 - 11-sep-2017


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