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Is there a relationship between pain, cognitive functioning, mood and motor activity in patients suffering from multiple sclerosis


- candidate number27794
- NTR NumberNTR6653
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR27-aug-2017
- Secondary IDsA2017.142 VUMC Medische Ethische Commissie
- Public TitleIs there a relationship between pain, cognitive functioning, mood and motor activity in patients suffering from multiple sclerosis
- Scientific TitlePain, cognition, mood , and motor activity in patients with multiple sclerosis
- ACRONYMn.a.
- hypothesisThe following hypotheses will be examined:
a. patients with multiple sclerosis who become cognitively impaired may experience an increase in pain experience (due to white matter lesions)
b. hyperesthesia is known to be predictive of central neuropathic pain. But could also hypesthesia be a predictor of central neuropathic pain
c. patients with multiple sclerosis suffer from comorbidities. It is hypothesized that particularly the affective aspects of pain show a relationship with comorbidities
d. It is hypothesized that there is a close relationship between a decline in motor activity, pain, and cognitive functioning in patients with multiple sclerosis
e. It is hypothesized that there is a close relationship between pain, motor activity and sleep in patients with multiple sclerosis
- Healt Condition(s) or Problem(s) studiedMultiple sclerosis (MS), Pain, Cognitive decline, Co-morbidity, Cognitive functioning, Mood
- Inclusion criteriapatients with multiple sclerosis
- Exclusion criteriapatients with a psychiatric history, focal neurological disorders, brain tumor, stroke, and alcohol abuse
- mec approval receivedyes
- multicenter trialno
- randomisedno
- groupParallel
- Type2 or more arms, non-randomized
- Studytypeobservational
- planned startdate 1-sep-2012
- planned closingdate1-jan-2018
- Target number of participants215
- Interventionsn.a.
- Primary outcomeEach substudy (5 in total) has its own primary outcome variables;please see the 5 hypothesis
- Secondary outcomen.a.
- TimepointsThere was only one moment of measurement (it is an observational study).
- Trial web siten.a.
- statusplanned
- CONTACT FOR PUBLIC QUERIESprof. dr. E.J.A. Scherder
- CONTACT for SCIENTIFIC QUERIESprof. dr. E.J.A. Scherder
- Sponsor/Initiator Vrije Universiteit Amsterdam
- Funding
(Source(s) of Monetary or Material Support)
Arnold Oosterbaan Hersenstichting
- PublicationsIn preparation
- Brief summarySummary
Pain expereince in patients with multiple sclerosis is very known phenomenon. However, no studies have been performed so far that examined possible alterations in pain experience when patients with multiple sclerosis become progressively cognitively impaired. Consequently, in cognitively impaired patients, we wish to examine the relationship between pain, mood, other comorbidities, cognition, and motor activity.
- Main changes (audit trail)
- RECORD27-aug-2017 - 1-sep-2017


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