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Generation R Study


- candidate number27555
- NTR NumberNTR6671
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR15-jul-2017
- Secondary IDsErasmus MC MEC-2012-165, NL40020.078.12; MEC 198.782/2001/31
- Public TitleGeneration R Study
- Scientific TitleGeneration R Study
- ACRONYMGeneration R
- hypothesisThe overall hypothesis of this study is that exposures in early life (fetal period and early childhood) are associated with health outcomes in later life.
- Healt Condition(s) or Problem(s) studiedGrowth, Behaviour, Cognitive development, Asthma, Allergy, Maternal health
- Inclusion criteriaPregnant women living in Rotterdam, the Netherlands, with a delivery date between April 2002 and January 2006.
- Exclusion criteriaNone
- mec approval receivedyes
- multicenter trialno
- randomisedno
- group[default]
- Type[default]
- Studytypeobservational
- planned startdate 24-dec-2001
- planned closingdate
- Target number of participants9778
- InterventionsNone, observational cohort study
- Primary outcomeThe study focuses on six primary research areas: (1) maternal health, (2) growth and physical development, (3) behaviour and cognitive development, (4) asthma and allergy, (5) diseases in childhood and (6) health care.
- Secondary outcomeNA
- TimepointsPregnancy
Birth
Infancy
Childhood (5 and 9 years)
Adolescence (13 and 16 years)
- Trial web sitewww.generationr.nl
- statusinclusion stopped: follow-up
- CONTACT FOR PUBLIC QUERIESProf. Dr. Vincent W.V. Jaddoe
- CONTACT for SCIENTIFIC QUERIESProf. Dr. Vincent W.V. Jaddoe
- Sponsor/Initiator Erasmus Medical Center
- Funding
(Source(s) of Monetary or Material Support)
Erasmus Medical Center, ZON-MW, The Netherlands Organization for Health Research and Development, Ministry of Health, Welfare and Sports (VWS)
- Publications
- Brief summaryThe Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and health from fetal life, childhood and young adulthood. This multidisciplinary study focuses on several health outcomes including behaviour and cognition, body composition, eye development, growth, hearing, heart and vascular development, infectious disease and immunity, oral health and facial growth, respiratory health, allergy and skin disorders of children and their parents. Main exposures of interest include environmental, endocrine, genomic (genetic, epigenetic, microbiome), lifestyle related, nutritional and socio-demographic determinants. In total, 9,778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. Response at baseline was 61%, and general follow-up rates until the age of 10 years were around 80%. Data collection in children and their parents includes questionnaires, interviews, detailed physical and ultrasound examinations, behavioural observations, lung function, Magnetic Resonance Imaging (MRI) and biological sampling. Genome and epigenome wide association screens are available. Eventually, results from the Generation R Study contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.
- Main changes (audit trail)
- RECORD15-jul-2017 - 11-sep-2017


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