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The effects of single session Competitive Memory Training (COMET) and yohimbine on the saliency of positive autobiographical memories.


- candidate number28019
- NTR NumberNTR6765
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR15-okt-2017
- Secondary IDsABR 63641 
- Public TitleThe effects of single session Competitive Memory Training (COMET) and yohimbine on the saliency of positive autobiographical memories.
- Scientific TitleThe effects of single session Competitive Memory Training (COMET) and yohimbine on the saliency of positive autobiographical memories.
- ACRONYMEnhancing the saliency of positive autobiographical memories
- hypothesisIf COMET increases the saliency of positive autobiographical memories, then memories that are activated during COMET (relative to no intervention control) should show an increase over time on all primary outcome measures, irrespective of medication administration. Therefore we expect that, relative to pre-test, ease of recollection, specificity, vividness and positive affectivity VAS scores at post-test and follow-up will be higher in memories that received COMET than memories that received no intervention.

If yohimbine strengthens intervention effects, then memories that are activated during COMET after yohimbine administration should show larger immediate and long-term effects of the intervention than memories that are activated during COMET after placebo administration. So, we expect that, relative to pre-test, ease of recollection, specificity, vividness and positive affectivity VAS scores at post-test and follow-up will be higher in memories in the yohimbine+COMET condition than memories in the placebo+COMET condition.
- Healt Condition(s) or Problem(s) studiedYohimbine, Autobiographical memories, Competitive Memory Training (COMET)
- Inclusion criteria- Age 18-30
- Written informed consent
- Body Mass Index (BMI) between 17.5 and 26
- Passing the medical screening (heart rate and blood pressure, medical interview)
- In females: the use of reliable contraceptives (birth control pills or a hormonal intrauterine device)
- Exclusion criteriaAssessed by physical exam:
- High blood pressure: systolic blood pressure over 140 mmHg, diastolic over 90 mmHg
- High heart rate: >90 beats per minute (bpm)

Assessed by interview:
- Inability to adequately read or speak Dutch
- Known sensitivity to yohimbine
- History of affective psychiatric disorders in the past 2 years
- Lifetime history of neurological disease (attention/memory disorders, epilepsy, convulsions)
- Current attention/memory problems
- Lifetime history of any cardiovascular problem, coronary insufficiency, congestive heart failure, heart block, tachycardia, myocardial infarction, hypertension, chronic obstructive pulmonary disease, bronchial asthma, renal disorders, liver disorders, diabetes
- Early age cardiovascular problems in first degree family members
- Fainting easily (can be indicative of cardiovascular problems)
- Chronic or frequent migraines
- Use of any medication
- Use of anti-inflammatory painkillers in the past 3 weeks
- Use of anxiolytics or antacids in the past week
- A score of ≥ 26 on the Anxiety Sensitivity Index (ASI: Reiss, Peterson, Gursky, & McNally, 1986) (in order to eliminate individuals who might have difficulty with any temporary symptoms induced by the yohimbine manipulation).
- Alcohol use of >2 units per day on one or more days during the past week
- Any drug use during the past month
- A score of ≥4 on the Fagerström Test for Nicotine Dependence (FTND: Heatherton, Kozlowski, Frecker, & Fagerstrom, 1991) (in order to eliminate individuals that are moderately or heavily dependent smokers).
- mec approval receivedno
- multicenter trialno
- randomisedyes
- masking/blindingDouble
- controlPlacebo
- groupCrossover
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 1-feb-2017
- planned closingdate30-aug-2018
- Target number of participants40
- InterventionsParticipants select four mildly positive autobiographical memories. They receive two intervention sessions. During each session, one memory will be activated using COMET procedures and one memory will receive no intervention. During one of these sessions, yohimbine HCL (20mg) will be administrated and during the other session placebo.
In total there are four within-subjects conditions: yohimbine+COMET, yohimbine+no intervention, placebo+COMET, and placebo+no intervention.
- Primary outcomeEase of recollection, specificity, vividness and positive affectivity of positive autobiographical memories at pre-test (baseline), post-test (after medication intake and COMET intervention) and 2-day follow-up measured with 100mm VASs.
- Secondary outcomePrior to and during the intervention, salivary α-amylase (sAA) levels, Skin Conductance Level (SCL) and Heart Rate (HR) are measured, as a manipulation check and in order to correlate noradrenaline/arousal levels with significant outcomes.
- TimepointsPre-test (prior to medication intake and intervention), post-test (immediately after medication intake and intervention), and 2-day follow-up test.
- Trial web site
- statusplanned
- CONTACT FOR PUBLIC QUERIES Suzanne Veen, van
- CONTACT for SCIENTIFIC QUERIES Suzanne Veen, van
- Sponsor/Initiator Prof. dr. Marcel A. van den Hout, Utrecht University, Faculty of Social Sciences, Division of Clinical Psychology
- Funding
(Source(s) of Monetary or Material Support)
TOP grant ZonMW
- Publications
- Brief summaryA within-subjects study to test the effect of a single session COMET (vs. no intervention) and yohimbine (vs. placebo) on the retrievability and quality of positive autobiographical memories in healthy subjects
- Main changes (audit trail)
- RECORD15-okt-2017 - 5-nov-2017


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