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Investigating red blood cells of sickle cell patients who started therapy.


- candidate number28105
- NTR NumberNTR6779
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR26-okt-2017
- Secondary IDsNL62011.041.17 
- Public TitleInvestigating red blood cells of sickle cell patients who started therapy.
- Scientific TitleInvestigating red blood cell deformability of sickle cell patients before and after the start of therapy.
- ACRONYMSickleCellScreen
- hypothesisRed blood cell deformability improves after start of therapy with Hydroxyurea.
- Healt Condition(s) or Problem(s) studiedSickle Cell anemia, HbSC, HbSS
- Inclusion criteria1.h No blood transfusion within the past 2 months
2. Diagnosed with sickle cell anemia (HbSS, HbSC or HbS/beta-thal)
3. Starting with Hydroxyurea therapy
4. Parents/legal guardians (and child, depending on age) or adult patients must give informed consent
- Exclusion criteria1. Blood transfusion within past 2 months
2. Body weight below 10 kg
3. Age <1 year
- mec approval receivedyes
- multicenter trialyes
- randomisedno
- group[default]
- Type[default]
- Studytypeobservational
- planned startdate 1-nov-2017
- planned closingdate1-okt-2018
- Target number of participants20
- InterventionsNot applicable
- Primary outcomeRed blood cell deformability
- Secondary outcomeChanges in red blood cell deformability over time and correlations with other laboratory parameters and clinical symptoms and signs.
- Timepointsbaseline, after 1, 3 and 6 months.
- Trial web site
- statusplanned
- CONTACT FOR PUBLIC QUERIES M.A.E. Rab
- CONTACT for SCIENTIFIC QUERIES M.A.E. Rab
- Sponsor/Initiator University Medical Center Utrecht (UMCU)
- Funding
(Source(s) of Monetary or Material Support)
RR Mechatronics
- Publications
- Brief summary
- Main changes (audit trail)
- RECORD26-okt-2017 - 11-nov-2017


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